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Moumoujus

PALMITOYL ARGININE.

Valuable CAS 58725-47-6 / HAIR CONDITIONING, SKIN CONDITIONING

Palmitoyl Arginine is a biosynthesized amino acid derivative, created by the esterification of palmitic acid with arginine. This modification significantly increases arginine's lipophilicity, facilitating its enhanced penetration and interaction with epidermal structures to deliver its comprehensive benefits.

Summary

Skin-conditioning agent Emollient Humectant Collagen booster Circulation enhancer Wound healing support Surfactant Emulsifying agent Hair conditioning agent

Science

Mechanism of Action

This compound works by leveraging its enhanced lipophilicity, allowing the arginine moiety to more effectively integrate into biological membranes. Palmitoyl Arginine actively supports microcirculation within cutaneous tissues, a key factor in nutrient delivery and waste removal. It stimulates endogenous collagen synthesis, contributing to improved skin elasticity and a visible reduction in fine lines and wrinkles. Furthermore, it fortifies the skin barrier through its moisturizing properties, crucial for maintaining optimal hydration. Its arginine component also contributes to nitric oxide production, essential for regulating epithelial cell proliferation and differentiation, thereby supporting the skin's natural wound healing and repair mechanisms.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The palmitoyl modification imparts amphiphilic characteristics, rendering it suitable as a surfactant or emulsifying agent. Optimal formulation requires careful consideration of solvent ratio, catalyst amount, and substrate ratio during its synthesis. Products incorporating Palmitoyl Arginine must be formulated to ensure non-irritancy.

Conflicts

  • Ingredients capable of forming N-nitroso compounds
  • Triethanolamine (TEA) with free Diethanolamine (DEA) impurities exceeding 0.64%

Safety

Safety Profile

CIR Status
Safe with restrictions
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) Expert Panel has determined Palmitoyl Arginine, as an amino acid alkyl amide, to be safe for use in cosmetics when formulated to be non-irritating. Strict adherence to formulation guidelines is necessary, specifically avoiding its inclusion in products where N-nitroso compounds might form. Additionally, if Triethanolamine (TEA) is present in a formulation, the concentration of free Diethanolamine (DEA) impurities must not exceed 0.64%, as mandated by the Panel.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Palmitoyl Arginine is a valuable modified amino acid derivative designed to enhance the delivery of arginine's benefits, supporting skin hydration, elasticity, and repair while requiring careful formulation.

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