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Moumoujus

PAEONIA SUFFRUTICOSA ROOT WATER.

Insufficient Data CAS 223747-88-4 / FLAVOURING, FRAGRANCE, PERFUMING, SKIN CONDITIONING

Derived from the root of the tree peony, Paeonia Suffruticosa Root Water is a multi-functional ingredient revered for its robust antioxidant and anti-inflammatory properties. Rich in bioactive compounds, it aims to protect skin from environmental stressors, soothe irritation, and promote a brighter, more even complexion.

Summary

antioxidant anti-inflammatory anti-aging skin brightening soothing moisturizing skin protecting cell renewal

Science

Mechanism of Action

This ingredient, along with related extracts, is abundant in bioactive compounds such as polyphenols, paeonol, and penta-O-galloyl-β-D-glucose (PGG). These compounds enable significant antioxidant activity by neutralizing free radicals and shielding skin from damaging oxygen species, thereby contributing to the reduction of dark spots, fine lines, and wrinkles. It exerts anti-inflammatory effects by mitigating skin inflammation, soothing irritation, and reducing redness, acting through pathways like AMPK/PI3K/Akt/Nrf2 to inhibit oxidative stress. Furthermore, it offers anti-aging benefits by enhancing skin tone and texture, diminishing hyperpigmentation, and ameliorating photoaging via the IRS1/PI3K/FOXO pathway. It also supports cell renewal, aids skin recovery from external aggressors, and contributes to skin brightening by reducing age spots and evening out tone, partly by inhibiting tyrosinase activity. Its moisturizing properties help maintain skin barrier function and reduce irritation.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Human Repeated Insult Patch Tests (HRIPT) involving 52 subjects demonstrated that a lotion containing 0.0015% Paeonia Suffruticosa Root Extract was neither irritating nor sensitizing.
  2. 02 An HRIPT conducted with 106 subjects concluded that a face mask formulation containing 0.5% Paeonia Suffruticosa Root Extract was well-tolerated, showing no signs of irritation or sensitization.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

For optimal stability, this ingredient should be incorporated into formulations when the temperature is below 50°C. It demonstrates broad compatibility with a wide array of personal care ingredients.

Safety

Safety Profile

CIR Status
Insufficient data
Max tested
0.5%
Sensitization risk Low

The CIR Expert Panel determined that available data are insufficient to conclude on the safety of Paeonia Suffruticosa Root Extract and related forms, including Paeonia Suffruticosa Root Water due to shared CAS numbers. Formulators are advised to ensure minimal impurities like heavy metals and pesticide residues. The Panel also cautioned that skin lightening is considered a drug effect, emphasizing that the ingredient should not cause depigmentation.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Paeonia Suffruticosa Root Water offers significant antioxidant, anti-inflammatory, and brightening potential, demonstrating low irritancy in studies on related extracts, yet its overall safety profile is currently categorized as having insufficient data by the CIR Expert Panel.

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