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PAEONIA SUFFRUTICOSA CALLUS EXTRACT.

Valuable / ANTIMICROBIAL, ANTIOXIDANT, HAIR CONDITIONING, SKIN PROTECTING

PAEONIA SUFFRUTICOSA CALLUS EXTRACT is a potent botanical ingredient derived from the tree peony, prized for its multifaceted benefits in precision skincare. It functions as a powerful anti-inflammatory and antioxidant, actively contributing to skin repair, collagen synthesis, and overall skin health. This extract is especially noted for its ability to soothe irritation and combat signs of aging.

Summary

Antioxidant Skin-Protecting Soothing Anti-aging Antimicrobial Hair Conditioning Skin Conditioning

Science

Mechanism of Action

This extract modulates skin response by significantly downregulating inflammatory factors, including IL-1α, IL-6, and TRPV1, and reducing histamine release in mast cells by nearly 74%, thereby calming irritation and redness. It offers robust antioxidant protection against free radical damage and oxidative stress. Furthermore, it exhibits anti-aging properties by promoting collagen production, repairing UVB-induced DNA damage, inhibiting collagen-degrading matrix metalloproteinases (MMPs), and reducing senescent cells. The extract also contributes to a more even skin tone through melanin regulation and possesses moisturizing and skin barrier-supporting characteristics.

Research

Clinical Evidence

Medium confidence
Effective range 0.1–1%
Optimal

1%

Key findings

  1. 01 Demonstrated an increase in total collagen content in human skin after 28 days of consistent application within a cosmetic formulation.
  2. 02 Significantly reduced key inflammatory factors (IL-1α, IL-6, TRPV1) in HaCaT cells following UVB exposure.
  3. 03 Reduced histamine release in mast cells by approximately 74%, indicating notable soothing and anti-allergic potential.
  4. 04 Significantly mitigated UVB-induced DNA damage, contributing to skin protection.
  5. 05 Exhibited no apparent cytotoxicity in human keratinocyte (HaCaT) cells and fibroblasts, confirming cellular safety.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Specific optimal pH for overall extract stability is not detailed. While paeonol, a component of Paeonia suffruticosa, can have stability issues, this concern is specific to the isolated compound and not characteristic of the callus extract itself.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

The CIR Expert Panel found insufficient data for several Paeonia Suffruticosa extracts, including those from bark, root, and the general 'Paeonia Suffruticosa Extract', but 'Paeonia Suffruticosa Callus Extract' was not explicitly evaluated. However, independent studies suggest that peony callus extract is considered a safe and promising ingredient for cosmetic use. It is listed in the European Union's Cosmetic Ingredient Database (CosIng) with assigned functions, and its non-cytotoxic profile further supports its safety in concentrations up to 1%.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Paeonia Suffruticosa Callus Extract is a valuable, multi-functional ingredient that significantly contributes to skin protection, soothing, and anti-aging efficacy across all skin types due to its potent anti-inflammatory, antioxidant, and collagen-boosting properties.

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