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PAEONIA OFFICINALIS CALLUS EXTRACT.

Valuable CAS 84929-40-8 / SKIN PROTECTING

Paeonia Officinalis Callus Extract is a biotechnologically derived ingredient offering comprehensive benefits for skin health. It is recognized for its potent anti-aging, anti-inflammatory, and antioxidant capabilities, working to enhance skin's natural repair processes, soothe sensitivity, and boost overall vitality and resilience.

Summary

Anti-aging Anti-inflammatory Antioxidant Skin protecting Collagen boosting Soothing Barrier support Seboregulating Antimicrobial Hair conditioning

Science

Mechanism of Action

This extract operates through multiple pathways to rejuvenate skin. It actively diminishes inflammatory factors, including IL-1α, IL-6, and TRPV1, while also inhibiting matrix metalloproteinases (MMPs) responsible for collagen degradation. It demonstrates efficacy in repairing UVB-induced DNA damage and reducing β-galactosidase activity, a key marker of cellular senescence. Its soothing action is partly due to a significant reduction in histamine release, alleviating skin sensitivity. Functioning as a robust antioxidant, it shields skin cells from oxidative stress, concurrently bolstering skin barrier function by improving mitochondrial activity, cell proliferation, and modulating genes vital for epidermal and stratum corneum health. Additionally, it shows potential for regulating hyperseborrhea, making it beneficial for managing oily skin concerns.

Research

Clinical Evidence

Medium confidence
Effective range 0.1–1%
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Data concerning the common 'dusting' or under-dosing practices for Paeonia Officinalis Callus Extract is not available in the provided research. Formulations should adhere to recommended concentrations based on efficacy and safety data.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

To preserve its beneficial compounds, Paeonia Officinalis Callus Extract is best incorporated into formulations during the cool-down phase, typically below 40°C (104°F). Ongoing research into advanced delivery systems, such as extracellular vesicles, aims to further enhance its stability and transdermal absorption.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

While the CIR Expert Panel has indicated 'insufficient data' for certain Paeonia suffruticosa-derived ingredients, Paeonia officinalis var. mascula callus extract has been demonstrated to be non-irritant on reconstructed human skin models. Furthermore, Paeonia suffruticosa callus extract shows negligible cytotoxicity, collectively suggesting a low sensitization risk for this ingredient in cosmetic formulations.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Paeonia Officinalis Callus Extract is a valuable, multi-functional ingredient with scientifically supported benefits for anti-aging, inflammation reduction, and antioxidant protection, making it suitable for all skin types, though the primary clinical studies available reference Paeonia suffruticosa callus extract.

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