Science
Mechanism of Action
PAEONIA MASCULA CALLUS EXTRACT exerts its beneficial effects by acting on key cellular processes. In vitro studies demonstrate its capacity to boost the viability, proliferation, and energy metabolism of human epidermal keratinocytes, particularly under oxidative stress, through enhanced mitochondrial activity. Furthermore, it precisely downregulates pro-inflammatory cytokines such as IL-1, IL-6, IL-8, and TNF-α. Concurrently, it upregulates GBA1 expression, a critical factor in enhancing the optimal barrier function of the stratum corneum.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
While the CIR Expert Panel has not specifically reviewed Paeonia mascula callus extract, a related extract (Paeonia mascula subsp. hellenica callus extract) has demonstrated non-irritant properties in a reconstructed human skin model and within a cosmetic formulation. Previous CIR assessments on other Paeonia suffruticosa-derived extracts were deemed to have insufficient data, but this assessment did not specifically cover Paeonia mascula callus extract.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Paeonia Mascula Callus Extract is a valuable botanical ingredient, demonstrating significant in vitro benefits for skin protection, barrier support, and inflammation modulation, making it promising for various skincare applications.
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References
Sources