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PAEONIA LACTIFLORA ROOT EXTRACT.

Valuable / SKIN CONDITIONING

A botanical extract derived from the Chinese Peony, Paeonia Lactiflora Root Extract delivers multi-faceted benefits for comprehensive skin health. It is particularly noted for its powerful antioxidant, anti-inflammatory, and brightening properties, effectively targeting skin sensitivity, uneven tone, and signs of aging.

Summary

Antioxidant Skin-soothing Brightening Anti-aging Skin conditioning

Science

Mechanism of Action

Primarily attributed to its active compound paeoniflorin, Paeonia Lactiflora Root Extract acts as a potent antioxidant, neutralizing reactive oxygen species (ROS) to protect skin from oxidative stress and environmental damage. It functions as an anti-inflammatory by inhibiting mediators such as prostaglandin E2 and nitric oxide, thereby reducing irritation and redness. The extract further supports skin brightening by regulating melanin production, stimulates collagen synthesis to improve elasticity and firmness, and enhances skin cell vitality for improved resilience and a revitalized complexion.

Research

Clinical Evidence

High confidence
Effective range 0.003–0.05%
Optimal

0.05%

Key findings

  1. 01 Demonstrated a significant reduction in melanin content on reconstructed pigmented human epidermis models: -28% in 2D and -27% in 3D, comparable to 4-n-butylresorcinol.
  2. 02 Markedly reduced TRPV1 receptors in skin keratinocytes by 67.05%. Eliminated LPS-induced inflammatory stress, leading to a reduction in TNF-α, IL-6, and IL-13 production by up to 55%. Also showed protective effects on type I collagen repair by decreasing MMP-9 activity.
  3. 03 Reduced TRPV1 receptors in skin keratinocytes by 52.24% and decreased IL-13 overproduction by 32.61%.
  4. 04 Reduced TRPV1 receptors in skin keratinocytes by 38.06%.

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
0.003%
Red flag below
0.003%

Paeonia Lactiflora Root Extract exhibits clinical efficacy at very low concentrations, with observed benefits starting at 0.003% for TRPV1 reduction. This indicates effectiveness even at minimal inclusion rates, suggesting it is not commonly 'dusted' in formulations for marketing purposes.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

For optimal preservation of beneficial compounds and effect, integrate into formulations during the cool-down phase (below 40°C / 104°F).

Synergies

  • Vitamin complex (B5)
  • Calcium

Safety

Safety Profile

CIR Status
Safe as used
Max tested
1%
Sensitization risk Low

Deemed safe for cosmetic use up to 1% concentration based on the Threshold of Toxicological Concern (TTC) approach. Generally considered safe with no significant side effects reported. However, individuals with known allergies to peonies or related plants should exercise caution and perform a patch test prior to widespread use.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Paeonia Lactiflora Root Extract is a valuable multi-functional ingredient offering significant antioxidant, anti-inflammatory, and brightening benefits, proven effective at low concentrations and well-suited for all skin types.

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