Science
Mechanism of Action
Paeonia Lactiflora Phytoplacenta Extract, rich in bioactive compounds like flavonoids, phenolics, and paeoniflorin, acts as a potent antioxidant by neutralizing reactive oxygen species and mitigating oxidative stress. It exhibits anti-inflammatory properties through reducing the production of inflammatory mediators such as TNF-α, IL-6, and IL-13, and deactivating inflammatory signaling pathways. For anti-aging, it stimulates collagen synthesis, enhances skin elasticity and firmness, and protects against degradation by inhibiting MMP-8 and MMP-9 production. It also contributes to skin brightening and evening tone by inhibiting tyrosinase, a key enzyme in melanin synthesis, thereby reducing pigmentation spots. Additionally, it strengthens the skin barrier, aids moisture retention, and offers protection from UV exposure.
Research
Clinical Evidence
High confidence1%
Key findings
- 01 Demonstrated an initial anti-inflammatory effect by reducing TRPV1 amount in skin keratinocytes by 38.06%.
- 02 Further reduced TRPV1 amount in skin keratinocytes by 52.24% and decreased IL-13 overproduction by 32.61%.
- 03 Eliminated inflammatory stress in skin keratinocytes by reducing TNF-α, IL-6 (up to 25%), and IL-13 (up to 55%). Additionally, it significantly reduced MMP-9 production by 70.27% in dermal fibroblasts and MMP-8 production by 39.32% in gingival fibroblasts, indicating strong anti-aging potential.
- 04 Showed significant depigmenting potential, decreasing melanin content by 27-30% in 2D and 3D reconstructed pigmented human epidermis models.
- 05 Exhibited significant inhibition of elastase, collagenase, and hyaluronidase enzymes, alongside decreasing melanin content without irritation.
Transparency
Dusting Analysis
While measurable cellular benefits, such as TRPV1 reduction, have been observed at concentrations as low as 0.003%, more comprehensive anti-inflammatory, anti-aging, and brightening effects are pronounced at 0.05% in vitro. Typical cosmetic use levels for visible results are often 1-3%. Formulations below 0.003% may offer minimal to no discernible benefit.
The Formula
Formulation
Stability
To preserve its beneficial compounds, the extract should be stored light-protected in a cool, dry place. In formulation, it is recommended to add during the cool-down phase (below 40°C / 104°F). Natural deep eutectic solvents (NADESs) have demonstrated a stabilizing effect on its active metabolites, suggesting enhanced stability within the pH range of 5-7.
Safety
Safety Profile
Paeonia lactiflora root extract has been evaluated as safe for cosmetic use at a 1% concentration based on the Threshold of Toxicological Concern (TTC) approach. It is generally well-tolerated and considered suitable for various skin types, including sensitive skin. No notable side effects or intolerances have been reported; however, a sensitivity test is advisable before widespread use.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Paeonia Lactiflora Phytoplacenta Extract is a valuable, multifaceted ingredient offering significant antioxidant, anti-inflammatory, anti-aging, and brightening benefits across various skin types, supported by in vitro efficacy and a favorable safety profile.
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References
Sources