Science
Mechanism of Action
This extract operates via multiple pathways to enhance skin health. Its key active compound, paeoniflorin, significantly reduces inflammatory markers like TNF-α and IL-13 in keratinocytes, soothing irritation and minimizing redness. It also functions as a powerful antioxidant, detoxifying cells from reactive oxygen species (ROS) through mitophagy and protecting against free radical damage. By inhibiting tyrosinase, it helps regulate melanin production, leading to brighter skin and reduced pigmentation. Furthermore, it supports skin structure by promoting type I collagen repair and inhibiting collagenase, while also offering anti-glycation benefits to maintain elasticity. Enhanced blood circulation due to paeoniflorin also contributes to improved nutrient delivery and skin renewal.
Research
Clinical Evidence
High confidenceOptimal effects for reducing inflammation are observed between 0.003% and 0.05%, while comprehensive anti-aging and revitalizing benefits are typically seen at concentrations up to 1%, the maximum safe use level.
Key findings
- 01 Reduced TNF-α overproduction by 148.82% and IL-13 overproduction by 68.63% in skin keratinocytes. Also decreased TRPV1 amount by 67.05%, MMP-8 production by 39.32%, and promoted type I collagen repair by reducing MMP-9 activity.
- 02 Reduced TNF-α overproduction by 105.49% and IL-13 overproduction by 32.61% in skin keratinocytes. Reduced TRPV1 amount by 52.24% and MMP-8 production by 39.05%.
- 03 Reduced TNF-α overproduction by 100.00% in skin keratinocytes. Also reduced TRPV1 amount by 38.06% and MMP-8 production by 45.75%.
- 04 Demonstrated 61.4% inhibition of tyrosinase and 77.7% inhibition of hyaluronidase in in vitro studies.
Transparency
Dusting Analysis
Paeonia Lactiflora Extract demonstrates measurable benefits across a wide range of concentrations, from as low as 0.003% for significant anti-inflammatory effects to up to its 1% maximum safe concentration for broader anti-aging and revitalizing properties. Its efficacy is well within typical formulation ranges, indicating it is not commonly dusted.
The Formula
Formulation
Stability
Optimal stability for the extract's active components is suggested around pH 6±0.3. High temperatures can degrade active ingredients, and alkaline conditions (above pH 7) may decompose active substances. Additionally, highly acidic conditions (around pH 3) can convert 1,2,3,4,6-O-pentagalloylglucose into gallic acid, impacting stability.
Safety
Safety Profile
A safety assessment using the Threshold of Toxicological Concern (TTC) approach found Paeonia lactiflora root extract safe for use in cosmetics at a 1% concentration. No notable side effects or intolerances are currently known, generally considering it a safe, natural-origin ingredient. FDA status regarding regulatory authority registrations for the root powdered extract is not available.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Paeonia Lactiflora Extract is a valuable botanical ingredient, offering comprehensive benefits from precise anti-inflammatory and antioxidant action at low concentrations to broader anti-aging and brightening effects at higher, safe-use levels.
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References
Sources