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Moumoujus

P-ANISYL BUTYRATE.

Insufficient Data CAS 6963-56-0 / PERFUMING

P-Anisyl Butyrate is a carboxylic ester predominantly employed in cosmetics for its aromatic properties, imparting a fruity-floral scent. While its direct function in precision skincare remains unconfirmed, it is theorized to undergo hydrolysis on the skin, potentially releasing compounds with biological activity.

Summary

Perfuming Agent Potential Anti-inflammatory Agent (via metabolites) Potential Skin Barrier Support (via metabolites)

Science

Mechanism of Action

Upon topical application, P-Anisyl Butyrate may hydrolyze into p-anisyl alcohol and butyric acid. Butyric acid, a short-chain fatty acid and postbiotic, has been investigated for its capacity to exert anti-inflammatory effects, modulate pro-inflammatory cytokines, foster anti-inflammatory proteins, and enhance skin barrier integrity. Additionally, butyric acid can function as a histone deacetylase (HDAC) inhibitor. However, the precise mechanism, rate of hydrolysis, and direct efficacy of P-Anisyl Butyrate in delivering these skincare benefits have not been explicitly elucidated.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Commonly dusted

P-Anisyl Butyrate's primary utility is as a perfuming agent. Its potential skincare benefits are contingent on hypothetical hydrolysis into active metabolites, for which direct efficacy data in topical formulations is absent, suggesting its inclusion in skincare might primarily be for fragrance rather than targeted therapeutic action.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

This stable, colorless liquid is susceptible to hydrolysis, particularly at extreme pH levels, which may lead to the formation of free butyric acid and an 'unpleasant butyric topnote'. It should be stored in sealed containers in a cool, ventilated environment, protected from oxidizers. It exhibits an estimated water solubility of 81.94 mg/L at 25 °C.

Conflicts

  • oxidisers

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

P-Anisyl Butyrate is categorized as having low toxicity. Within its fragrance structural group, toxicologic and dermatologic assessments, often using read-across materials like p-anisyl acetate, indicate a generally low potential for irritation or sensitization at current exposure levels. Notably, the FDA no longer permits its use as a synthetic food flavoring.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While P-Anisyl Butyrate carries theoretical benefits through its potential metabolites, there is currently insufficient direct evidence to establish its efficacy as a precision skincare active; its primary established role is a fragrance agent.

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