Science
Mechanism of Action
The precise mechanism by which Ozonized *Pereskia grandifolia* Callus Culture Extract imparts its skin conditioning properties has not been elucidated in the available research data.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
Current data does not indicate that Ozonized *Pereskia grandifolia* Callus Culture Extract is typically 'dusted' at sub-efficacious concentrations. However, a lack of documented efficacy data prevents a comprehensive analysis of optimal or minimal effective percentages.
The Formula
Formulation
Stability
Information regarding the stability profile of Ozonized *Pereskia grandifolia* Callus Culture Extract in various formulation environments is currently unavailable.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) panel has not yet reviewed Ozonized *Pereskia grandifolia* Callus Culture Extract. No specific safety assessments for this ozonized callus culture extract by CIR, SCCS, or FDA were found. Preliminary studies on aqueous leaf extracts of *Pereskia grandifolia* demonstrated *in vitro* hemolysis at concentrations above 10 µg, suggesting a need for more robust *in vivo* toxicity and safety studies, particularly for therapeutic applications. Conversely, acute oral toxicity studies using crude *Pereskia grandifolia* extracts in mice at doses up to 2500 mg/kg showed no mortalities or adverse effects. The maximum safe topical concentration for this specific ozonized extract remains undefined.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Due to a substantial absence of documented clinical efficacy, mechanism of action, detailed safety assessments, and formulation guidelines, the current utility of Ozonized *Pereskia grandifolia* Callus Culture Extract in precision skincare is largely undetermined.
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References
Sources