Science
Mechanism of Action
This ingredient operates via the Criegee reaction, where ozone reacts with the oil's unsaturated bonds to form stable cyclic trioxolane derivatives (Criegee ozonides). These ozonides efficiently deliver active oxygen to deeper skin layers without causing primary irritation, inhibiting a broad spectrum of microbes and reducing inflammation. Furthermore, it supports enhanced oxygen supply for detoxification and revitalization, and potentially stimulates collagen synthesis for anti-aging effects.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 Demonstrates efficacy in healing cutaneous wounds, reducing microbial infection, modulating inflammation, stimulating angiogenesis, and improving oxygen metabolism. It also alleviates skin burn symptoms and prevents post-lesion hyperpigmentation.
- 02 Topical application significantly improves epithelial healing at gingival surgical sites.
- 03 When combined with α-bisabolol, it achieved a substantial and progressive reduction in wound surface area (34%, 59%, and 73% after 7, 14, and 30 days, respectively) in vascular leg ulcers, outperforming control treatments.
- 04 Ozonated camellia oil effectively inhibited inflammation and healed lesions within 7 days in murine models of atopic dermatitis. While specific studies on ozonized castor oil concentrations are limited, general ozonated oils are suggested at 1-2% for lip balms, 2-3% for moisturizers, and 3-4% for cleansers and anti-aging products.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Ozonides are typically liquid or semi-solid at room temperature. For optimal potency and extended shelf life, refrigeration (5-7°C or below 21°C) is highly recommended, as ambient or elevated temperatures can lead to rapid chemical degradation. Long-term storage in refrigerated conditions can extend shelf life significantly (up to ten years for some ozonated oils). Increased viscosity is a characteristic, directly correlating with ozonation time, with viscosity decreasing as temperature rises.
Synergies
- Alpha-bisabolol (for enhanced wound healing)
Safety
Safety Profile
A systematic review indicates ozonated liquids, including oils, are generally well-tolerated and pose no significant dermatological risks. Studies have shown no evidence of cytotoxic effects of ozonated neem oil or water at concentrations up to 4 ppm on human skin cells. Rare reported adverse effects include a brief burning sensation in some patients and isolated instances of desquamation (skin peeling). Specific regulatory status by CIR, SCCS, or FDA for 'OZONIZED CASTOR OIL' as a cosmetic ingredient has not yet been established.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Ozonized Castor Oil offers a potent blend of healing, antimicrobial, and anti-inflammatory benefits, making it a valuable active for diverse skincare applications across all skin types, despite its unreviewed regulatory status.
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References
Sources