Science
Mechanism of Action
Oxodeoxy guanosine, specifically 8-oxo-2'-deoxyguanosine (8-OHdG), functions as a robust endogenous antioxidant by effectively scavenging reactive oxygen species (ROS) that contribute to cellular damage. It also inhibits the expression of Matrix Metalloproteinases (MMPs), enzymes implicated in collagen degradation, thereby protecting the skin from photodamage. Furthermore, 8-OHdG exhibits potent anti-inflammatory effects by attenuating the activity of Rac1, a key protein involved in inflammatory cascades, ultimately supporting skin resilience against oxidative stress and inflammation.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
No data available regarding dusting potential.
The Formula
Formulation
Stability
Oxodeoxy guanosine (CAS 79581-52-5) is reported to be soluble in water. While optimal pH range is not specified, related forms like 8-hydroxy guanosine (CAS 3868-31-3) can show stability for up to 4 years at -20°C as a crystalline solid and approximately one year at room temperature in general compound form.
Safety
Safety Profile
No specific review by the Cosmetic Ingredient Review (CIR), Scientific Committee on Consumer Safety (SCCS), or FDA for cosmetic use has been conducted for Oxodeoxy Guanosine (8-hydroxy-2'-deoxyguanosine). While dermal toxicity for this specific compound remains undetermined, a related raw material, 8-Hydroxyguanosine, is classified to cause skin irritation, serious eye irritation, and potential respiratory irritation in its pure, undiluted form according to GHS standards on PubChem.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Oxodeoxy Guanosine presents a valuable profile as a potent endogenous antioxidant and anti-inflammatory agent with demonstrated photoprotective benefits in animal models, though further human clinical data and safety reviews are needed for comprehensive assessment.
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References
Sources