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Moumoujus

OSTERICUM KOREANUM EXTRACT.

Insufficient Data CAS - / SKIN CONDITIONING

Ostericum Koreanum Extract is derived from the Korean Angelica root, recognized for its potent antioxidant and anti-inflammatory properties. Research indicates its ability to stabilize mast cells and reduce histamine release, suggesting potential benefits for sensitive or reactive skin conditions. It also shows promise in mitigating oxidative stress.

Summary

Skin Conditioning Antioxidant Anti-inflammatory

Science

Mechanism of Action

This extract exerts its anti-inflammatory effects by modulating key cellular pathways, specifically inhibiting the phosphorylation of ERK1/2 and p38 MAPK, and blocking the NFKB pathway in mast cells. It also reduces nitric oxide (NO) production in LPS-activated murine macrophages. Its significant antioxidant capacity is attributed to its high polyphenol content and direct radical scavenging ability.

Research

Clinical Evidence

Medium confidence
Effective range 50 µg/mL–1000 µg/mL%
Optimal

N/A

Key findings

  1. 01 Demonstrated anti-obesity, anti-diabetic, and antioxidant effects in 3T3-L1 preadipocytes.
  2. 02 Exhibited significant antioxidant activity with 50% radical scavenging in ABTS and DPPH assays.
  3. 03 Significantly decreased compound 48/80-induced histamine release and suppressed mast cell degranulation in rat peritoneal mast cells (RPMC).
  4. 04 Attenuated allergic rhinitis in a mouse model by decreasing serum histamine and IgE levels, and modulating Th1/Th2 cytokine balance.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Isoimperatorin, a key component, shows stability up to 70 °C during extraction processes, indicating good thermal stability for formulation.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No specific safety assessments by Cosmetic Ingredient Review (CIR), Scientific Committee on Consumer Safety (SCCS), or FDA were found. Paula's Choice indicates no current rating for this ingredient.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Ostericum Koreanum Extract demonstrates promising in vitro antioxidant and anti-inflammatory effects, including mast cell stabilization, but lacks sufficient CIR/SCCS safety reviews and direct human topical efficacy data to provide a precise recommendation.

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