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Moumoujus

OSMANTHUS FRAGRANS LEAF EXTRACT.

Valuable / HUMECTANT, SKIN CONDITIONING

Osmanthus fragrans Leaf Extract is a botanical active revered for its multifaceted benefits in precision skincare. This extract offers potent anti-inflammatory and antioxidant properties, alongside promising effects for skin brightening and regeneration. It is a valuable component for addressing skin sensitivity, oxidative stress, and hyperpigmentation.

Summary

Antioxidant Anti-inflammatory Skin Brightening Depigmenting Antimicrobial Wound Healing Skin Conditioning Humectant

Science

Mechanism of Action

This botanical extract operates through several biological pathways to enhance skin health. It acts as a powerful antioxidant by directly neutralizing free radicals, specifically observed in its capacity to scavenge DPPH and ABTS radicals. Its anti-inflammatory action is achieved by inhibiting the expression of key pro-inflammatory mediators such as inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 proteins, and by reducing the activity of NF-κB, a central regulator of inflammation. Furthermore, it modulates the MITF-Tyrosinase signaling pathway, thereby inhibiting tyrosinase activity and melanin formation, leading to skin whitening and depigmenting effects. The extract also demonstrates antibacterial capabilities and supports the skin's natural wound healing processes.

Research

Clinical Evidence

Medium confidence
Effective range 100 μg/mL–100 μg/mL%
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

There is no available research data to suggest that Osmanthus fragrans Leaf Extract is commonly 'dusted' at sub-efficacious percentages in cosmetic formulations, nor are specific dusting thresholds or red flag percentages identified.

The Formula

Formulation

Solubility
Water
Optimal pH 3.5 – 7
0 7 14

Stability

To maintain ingredient integrity and efficacy, temperatures exceeding 60°C should be avoided during formulation and storage.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While Osmanthus fragrans Leaf Extract has not been specifically reviewed by CIR, SCCS, or FDA, safety studies on Osmanthus fragrans flower extract (OFFE) demonstrated a high safety profile. No acute lethal effects were observed at doses up to 10g/kg body weight in animal models, and a no-observed adverse-effect-level (NOAEL) exceeded 2.00g/kg body weight in a 90-day subchronic toxicity study, indicating low systemic toxicity. The ingredient is also listed in COSMILE Europe, affirming its general acceptance for cosmetic applications in European markets. Overall irritancy is considered low based on available data.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Osmanthus fragrans Leaf Extract offers significant anti-inflammatory and antioxidant benefits, with promising skin brightening potential, making it a valuable active for diverse precision skincare formulations targeting skin health and appearance.

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