Science
Mechanism of Action
This extract functions as a robust antioxidant by effectively neutralizing free radicals, including DPPH and ABTS. Its anti-inflammatory action stems from inhibiting key inflammatory markers like iNOs and COX-2. For pigmentation concerns, Osmanthus Fragrans Flower Extract intervenes by modulating MITF-Tyrosinase signaling, thereby reducing melanin synthesis. Emerging research also suggests roles in supporting wound healing, collagen production, and demonstrating anti-aging effects, while its essential oil component provides astringent qualities.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 A methanol extract at 40 μg/mL demonstrated strong DPPH radical scavenging activity (91.3%), comparable to green tea (93.4%). Key isolated compounds like rutin, verbascoside, and phillygenin exhibited potent DPPH radical scavenging with IC50 values of 19.1, 10.3, and 6.2 μM, respectively, and also showed H2O2 scavenging ability with IC50 values of 10.5, 23.4, and 13.4 μM, respectively.
- 02 Osmanthus fragrans flower extract (OFE) provided neuroprotective, free radical scavenging, and antioxidant benefits, alongside a protective effect against d-galactose-induced aging in an ICR mouse model.
- 03 An ethanol extract displayed effective DPPH scavenging activity (IC50 of 0.173 ± 0.004 kg/L) and a high FRAP value (830.620 ± 6.843 g Trolox/kg). It significantly decreased nitric oxide (NO) levels and suppressed the proliferation of RAW-264.7 and DU-145 cell lines.
- 04 An aqueous extract from Osmanthus fragrans flowers (OFFE) modified melanogenesis through MITF-Tyrosinase signaling modulation, resulting in a depigmenting action, indicating its potential as a skin-whitening agent.
Transparency
Dusting Analysis
No data is available within the provided research to assess the likelihood of Osmanthus Fragrans Flower Extract being used at sub-efficacious 'dusting' levels in cosmetic formulations.
The Formula
Formulation
Stability
To maintain integrity and efficacy, avoid exposing the extract to temperatures exceeding 60°C.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) has not specifically reviewed Osmanthus Fragrans Flower Extract, nor has the Scientific Committee on Consumer Safety (SCCS) issued an opinion. Its FDA status in cosmetics is not explicitly documented in the provided data. General regulatory guidance notes that cosmetics are not mandated to undergo pre-market safety testing.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Osmanthus Fragrans Flower Extract is a valuable botanical ingredient, offering confirmed antioxidant, anti-inflammatory, and depigmenting benefits, suitable for a wide range of skin types and cosmetic applications.
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