Science
Mechanism of Action
This extract fundamentally reduces sebum production by inhibiting 5-α reductase type 1 expression in epidermal keratinocytes, consequently decreasing both the enzyme's activity and squalene synthesis. Beyond sebum control, it exhibits significant free radical scavenging capabilities due to its antioxidant compounds. Its anti-inflammatory action, attributed to constituents like rosmarinic acids and sinensetin, helps modulate immune responses, while also demonstrating anti-allergic effects by modulating Th2 cytokines.
Research
Clinical Evidence
High confidence2%
Transparency
Dusting Analysis
Clinical data provides a clear and effective concentration of 2% for demonstrable skin benefits, indicating its use is likely for targeted efficacy rather than as a 'dusting' ingredient.
The Formula
Formulation
Stability
Optimal stability of the extract's marker compounds is achieved at temperatures below 30°C and 75% relative humidity. Elevated temperatures (e.g., 40°C/75% RH or 60°C/85% RH) can compromise integrity and may induce color changes during storage.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) has not conducted a specific review of Orthosiphon Stamineus Leaf Extract. It is regulated in the U.S. as a dietary herb under DSHEA, not as a drug. A patch test on 30 volunteers using an essence containing the extract showed no irritation, suggesting a low potential for skin sensitization or irritation.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Orthosiphon Stamineus Leaf Extract is a valuable botanical ingredient, clinically shown to significantly reduce skin oiliness and pore size, making it highly effective for managing oily, blemish-prone, and sensitive skin while providing antioxidant and anti-inflammatory benefits.
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