Science
Mechanism of Action
L-Threonine is a fundamental amino acid crucial for the structural integrity of collagen and elastin, contributing to the skin's firmness and resilience. It also functions as a humectant, enhancing skin hydration. L-Ornithine is understood to stimulate the transcription factor HIF-1α, which can lead to increased fatty tissue volume. This action may provide a 'lipofilling-like' effect, visibly diminishing the appearance of deep wrinkles, particularly in areas like the nasolabial folds. Therefore, Ornithyl Threonine is inferred to deliver comprehensive anti-aging benefits, including improved hydration, enhanced skin structure, and a noticeable plumping effect.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
As a water-soluble dipeptide, Ornithyl Threonine is expected to exhibit general stability across a range of pH values, characteristic of amino acids existing as zwitterions. Precise optimal pH parameters for its stability, however, are not explicitly detailed in current research.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel generally regards alpha-amino acids as safe for cosmetic use, primarily functioning as conditioning agents. L-Ornithine is recognized by European Union authorities as a safe cosmetic ingredient, although individual sensitivities cannot be entirely excluded. However, there is currently no specific safety assessment by CIR, SCCS, or FDA for Ornithyl Threonine as a distinct dipeptide. Oral studies on its individual components, L-Ornithine hydrochloride and L-Threonine, showed no observed adverse effect levels (NOAEL) at 12 g/person/day over four weeks in healthy adult males.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Ornithyl Threonine presents a promising inferred mechanism for skin plumping, hydration, and anti-aging benefits due to its constituent amino acids, though specific clinical data and safety assessments for the dipeptide are currently limited.
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References
Sources