Science
Mechanism of Action
This botanical extract promotes epidermal regeneration and cutaneous repair by actively stimulating keratinocyte differentiation. It reinforces the skin's natural barrier, regulating hydration to maintain flexibility and softness. Furthermore, it possesses potent anti-inflammatory properties through the inhibition of nuclear factor kappa B1 (NF-κB1) gene expression, nitric oxide production, leukotriene biosynthesis (5-lipoxygenase), and the activity of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes. The extract also exhibits antioxidant capacity and specific antibacterial activity against certain Gram-positive bacteria.
Research
Clinical Evidence
High confidence2%
Key findings
- 01 Flowers extract significantly promoted wound healing, achieving complete recovery in 6 days, a notable acceleration compared to 17 days for the ointment base alone.
- 02 This concentration is recommended for anti-aging and mature skin moisturizers, stimulating epidermal regeneration, promoting cutaneous repair, strengthening the skin barrier, and maintaining hydration.
- 03 Specific compounds (4β,15-dihydro-3-dehydrozaluzanin C and zaluzanin C) demonstrated strong inhibition of LPS/IFN-γ-induced nitric oxide production and suppressed COX-2 and NF-κB1 gene expression. Luteolin further inhibited leukotriene biosynthesis by 74.6 ± 8.8%.
- 04 In vitro, a chloroform extract effectively inhibited iNOS (76.7 ± 7.0%), 5-LOX (62.6 ± 6.8%), and COX-2 enzyme (61.8 ± 9.0%).
- 05 A methanol seed extract exhibited significant antibacterial activity against Gram-positive bacteria, specifically Staphylococcus epidermidis and Micrococcus luteus.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
This ingredient is frequently supplied as a hydro-alcoholic extract, utilizing both alcohol and water for stability and delivery.
Safety
Safety Profile
Approved for cosmetic applications in Europe, the United States, Japan, and Australia, and is organically certified by Ecocert. EWG Skin Deep rates it as a LOW concern for Cancer, Allergies & Immunotoxicity, Developmental and Reproductive Toxicity, and Use Restrictions.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This highly versatile botanical extract offers robust skin barrier support, accelerated wound healing, significant anti-inflammatory benefits, and hydration, making it a valuable asset for diverse skincare formulations, particularly for compromised or mature skin.
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