Science
Mechanism of Action
This extract exerts its anti-inflammatory effects by antagonizing Toll-like receptor 4 (TLR4) signaling, thereby reducing the release of pro-inflammatory cytokines like IL-8 and TNF-α in neutrophils. Rich in flavonoids and phenolic compounds, it functions as an antioxidant, neutralizing free radicals and protecting against UV-induced photoaging. It further inhibits enzymes such as renal human hyaluronidase-1 and cytosolic phospholipase A2α, contributing to its anti-inflammatory action. Additionally, it can inhibit tyrosinase, offering potential skin brightening benefits, and demonstrates antibacterial, antifungal, and antiseborrhoeic activities to regulate sebum production and condition the skin.
Research
Clinical Evidence
Medium confidence0.01%
Key findings
- 01 A dichloromethane extract (0.0025%-0.01%) showed concentration-dependent inhibition of IL-8 and TNF-α release from LPS-stimulated human neutrophils.
- 02 A methanolic extract (0.002%) from aerial parts demonstrated antifungal activity against Penicillium aurantiogriseum.
- 03 A methanolic extract (0.00394%) exhibited inhibitory activity of cytosolic phospholipase A2α (IC50).
Transparency
Dusting Analysis
Effective concentrations for specific biological activities, such as anti-inflammatory and antifungal effects, are observed in the range of 0.002% to 0.01%. Use significantly below this range, particularly below 0.002%, when strong efficacy claims are made, may indicate insufficient concentration for intended benefits.
The Formula
Formulation
Stability
The ingredient may have potential heat sensitivity for certain active compounds; infusions are recommended over decoctions for medicinal uses to preserve volatile components.
Safety
Safety Profile
No cytotoxicity was observed in human gingival fibroblast cells at concentrations up to 0.04% (400 µg/mL). The EWG Skin Deep database rates the ingredient as 'Low' concern for cancer, allergies & immunotoxicity, and developmental/reproductive toxicity.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Ononis Spinosa Root Extract is a valuable multi-functional ingredient offering significant anti-inflammatory, antioxidant, and sebum-regulating benefits across all skin types, with a low risk of irritation or comedogenicity.
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