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OLIGOPEPTIDE-91 SH-POLYPEPTIDE-9.

Questionable / HAIR CONDITIONING

OLIGOPEPTIDE-91 SH-POLYPEPTIDE-9 is a synthetic fusion peptide engineered to stimulate angiogenesis, thereby optimizing nutrient delivery to skin cells. This enhanced microcirculation supports overall skin vitality, leading to improvements in texture and tone.

Skin conditioning Hair conditioning Promotes microcirculation Enhances nutrient delivery Improves skin texture Supports skin firmness Anti-aging

Science

This ingredient functions as a single chain synthetic fusion peptide, where SH-Polypeptide-9, a form of Vascular Endothelial Growth Factor (VEGF), plays a crucial role. It actively stimulates angiogenesis, the formation of new blood vessels, by binding to specific receptors on endothelial cells. This binding initiates a cellular cascade that promotes cell proliferation and the development of new microvascular structures. The resulting increase in microcirculation ensures that essential nutrients and oxygen are efficiently delivered to the dermal layers, contributing to improved skin tone and texture. Furthermore, it boosts the production of proteins vital for cell restructuring, promoting a smoother and firmer skin appearance. The peptide also enhances vascular wall permeability, facilitates monocyte migration through skin tissues, and supports the survival of newly formed blood vessels by inhibiting cellular apoptosis and promoting cell growth and division. Broader peptide-related benefits include maintaining skin health, enhancing smoothness, contributing to a more even complexion, and forming a protective barrier against environmental aggressors.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH N/A
0 7 14

Safety

CIR Status
Not reviewed
Sensitization risk Unknown

The European Commission's CosIng database indicates no specific review by the SCCS for OLIGOPEPTIDE-91 SH-POLYPEPTIDE-9. It is important to note that ingredients with Vascular Endothelial Growth Factor (VEGFA) activity, such as SH-Polypeptide-9, may contribute to the progression of psoriasis. Therefore, caution is advised for individuals with this condition when using products containing this ingredient. Similar prudence is recommended for individuals with high skin cancer risk factors due to the cell-proliferative nature associated with such growth factors.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Questionable

While mechanistically promising for skin vitality and texture improvement through enhanced microcirculation, the lack of specific safety review and caution advised for individuals with psoriasis or high skin cancer risk factors warrant careful consideration.


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