Science
Mechanism of Action
This ingredient functions as a single chain synthetic fusion peptide, where SH-Polypeptide-9, a form of Vascular Endothelial Growth Factor (VEGF), plays a crucial role. It actively stimulates angiogenesis, the formation of new blood vessels, by binding to specific receptors on endothelial cells. This binding initiates a cellular cascade that promotes cell proliferation and the development of new microvascular structures. The resulting increase in microcirculation ensures that essential nutrients and oxygen are efficiently delivered to the dermal layers, contributing to improved skin tone and texture. Furthermore, it boosts the production of proteins vital for cell restructuring, promoting a smoother and firmer skin appearance. The peptide also enhances vascular wall permeability, facilitates monocyte migration through skin tissues, and supports the survival of newly formed blood vessels by inhibiting cellular apoptosis and promoting cell growth and division. Broader peptide-related benefits include maintaining skin health, enhancing smoothness, contributing to a more even complexion, and forming a protective barrier against environmental aggressors.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
The European Commission's CosIng database indicates no specific review by the SCCS for OLIGOPEPTIDE-91 SH-POLYPEPTIDE-9. It is important to note that ingredients with Vascular Endothelial Growth Factor (VEGFA) activity, such as SH-Polypeptide-9, may contribute to the progression of psoriasis. Therefore, caution is advised for individuals with this condition when using products containing this ingredient. Similar prudence is recommended for individuals with high skin cancer risk factors due to the cell-proliferative nature associated with such growth factors.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While mechanistically promising for skin vitality and texture improvement through enhanced microcirculation, the lack of specific safety review and caution advised for individuals with psoriasis or high skin cancer risk factors warrant careful consideration.
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