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Moumoujus

OLIGOPEPTIDE-78.

Valuable / SKIN CONDITIONING

OLIGOPEPTIDE-78 is a sophisticated biomimetic peptide engineered to repair and fortify hair by replicating key keratin structures. Beyond its profound impact on hair health, it offers antioxidant and antibacterial protection, while also showing promise in optimizing skin's natural renewal processes and enhancing overall appearance.

Summary

Hair conditioning Hair repair & strengthening Enhances hair appearance (volume, brightness, luster, texture) Improves hair combability Antioxidant Antibacterial Supports skin renewal Anti-aging (skin) Skin plumping Surfactant

Science

Mechanism of Action

This synthetic bioactive peptide operates distinctly in hair and skin. For hair, it functions as a biomimetic peptide, precisely replicating a specific sequence of Type II keratin, a vital structural protein. Its sulfur-containing amino acids, particularly cysteine, form robust disulfide bonds within the hair shaft. This intricate process stabilizes keratin fibers, directly protecting the hair fiber and reconnecting broken keratin chains resulting from thermal or chemical damage, thereby restoring intrinsic strength and elasticity. Furthermore, it exhibits protective antioxidant and antibacterial properties. In skin, OLIGOPEPTIDE-78 is designed to mimic signaling sequences within the extracellular matrix, interacting with cellular receptors to modulate communication pathways essential for skin homeostasis and the optimization of natural renewal.

Research

Clinical Evidence

Medium confidence
Effective range 0.005–5%
Optimal

0.05%

Key findings

  1. 01 An effective concentration range of 0.005-0.05% is identified for most hair care formulations, specifically addressing androgenetic alopecia, thinning hair, and scalp sensitivity.
  2. 02 Higher potency applications, such as hair serums and ampoules, demonstrate efficacy at concentrations ranging from 2% to 5%.
  3. 03 For rinse-off products like shampoos and conditioners, concentrations between 0.5% and 2% are suitable.
  4. 04 This peptide enhances hair appearance and feel, improving combability, volume, brightness, luster, and texture, while also providing antioxidant and antibacterial protection against oxidative stress and infection.
  5. 05 It repairs keratin integrity compromised by thermal and chemical aggressions (e.g., bleaching, coloring, heat styling), leading to healthier, shinier, and more resilient hair.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 6.5
0 7 14

Stability

Optimal stability for OLIGOPEPTIDE-78 in hair care formulations is achieved within a pH range of 5.0–6.5. For storage, unopened original containers should be kept in a cool, dry place away from direct sunlight, heat, and moisture. Short-term preservation is recommended at 2-8℃, while long-term storage requires -20℃±5℃, ensuring a shelf life of 24 months.

Conflicts

  • Compatibility testing is advised when formulated alongside Minoxidil.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While supplier information suggests OLIGOPEPTIDE-78 is 'completely safe and natural' and 'scientifically tested to ensure effectiveness and gentleness,' official reviews by regulatory bodies such as CIR, SCCS, or FDA are currently unavailable. SkinSAFE classifies it as 'Irritant Free', 'Fragrance Free', 'Paraben Free', 'MCI/MI Free', 'Nickel Free', 'Gluten Free', 'Soy Free', 'Propylene Glycol Free', and 'Balsam of Peru Free,' also deeming it 'Baby SAFE' and 'Eyelid SAFE.'

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

OLIGOPEPTIDE-78 is a valuable biomimetic peptide offering significant benefits for hair repair, strengthening, and aesthetics, with emerging potential for skin renewal and anti-aging.

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