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OLIGOPEPTIDE-180 PORPHYRA 334.

Valuable / ANTIOXIDANT, HAIR CONDITIONING, SKIN CONDITIONING, SKIN PROTECTING, UV FILTER

OLIGOPEPTIDE-180 PORPHYRA 334 is a sophisticated marine-derived ingredient harnessing the photoprotective and antioxidant capabilities of Porphyra-334, a mycosporine-like amino acid. It efficiently absorbs UV radiation and mitigates oxidative stress, leading to visible improvements in skin firmness and the reduction of periorbital wrinkles.

Summary

Antioxidant Hair Conditioning Humectant Skin Conditioning Skin Protecting UV Filter

Science

Mechanism of Action

This ingredient functions as a potent natural UV filter, effectively absorbing both UV-A and UV-B radiation, particularly around 334 nm, and safely dissipating this energy as heat to prevent direct photochemical damage to cellular DNA and proteins. At a molecular level, it actively suppresses the formation of Reactive Oxygen Species (ROS) following UVA exposure, thereby preventing lipid peroxidation and safeguarding against oxidative stress and subsequent cellular damage. It also inhibits Matrix Metalloproteinases (MMPs), enzymes known to degrade essential skin components like collagen and elastin, thus helping to preserve skin structure and elasticity. Furthermore, Porphyra-334 elevates levels of critical extracellular matrix components, including procollagen, type I collagen, and elastin, stabilizes cell membranes, and contributes to redox homeostasis by activating the cytoprotective Keap1-Nrf2-ARE pathway, enhancing the skin's intrinsic defense mechanisms.

Research

Clinical Evidence

Medium confidence
Effective range 0.001–0.001%
Optimal

0.001%

Key findings

  1. 01 A clinical study demonstrated that a test product containing 0.001% of the Porphyra-334 component, applied over 6 to 12 weeks, significantly improved multiple parameters of periorbital wrinkles (R1, R2, R3, R4, R5) and overall visual assessment when compared to a control.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 2 – 11
0 7 14

Stability

Porphyra-334 exhibits general stability within a broad pH range of 2 to 11 and at temperatures below 40°C. While relatively stable in acidic conditions, it is noted to be unstable in alkaline environments. Liquid mycosporine-like amino acids are susceptible to oxidation and pigment deepening at higher temperatures, with optimal crystallization processes maintained below 55°C.

Conflicts

  • alkaline environments

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Unknown

There is no specific CIR, SCCS, or FDA regulatory status explicitly found for the combined ingredient 'OLIGOPEPTIDE-180 PORPHYRA 334'. However, its core component, Porphyra-334, is well-characterized for its photoprotective and antioxidant bioactivity. In vivo studies conducted on UVB-irradiated mouse models showed that topical or oral administration significantly reduced erythema, epidermal thickening, and oxidative stress markers, improving skin barrier parameters without observable toxicity. In vitro, it displayed no cytotoxic effect on 3T3-L1 cells at concentrations below 200 µg/mL.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

OLIGOPEPTIDE-180 PORPHYRA 334 is a valuable ingredient for precision skincare, demonstrating robust photoprotection, potent antioxidant activity, and clinically observed improvements in periorbital wrinkles, making it highly beneficial for anti-aging and skin protective formulations.

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