Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The Oligopeptide-1 component exhibits significant pH sensitivity, requiring the final formulation's pH to be adjusted between 5 and 8 before its diluted solution is incorporated. The specific complex, OLIGOPEPTIDE-179 SH-OLIGOPEPTIDE-1 SP, may also present aesthetic, stability, or other formulation challenges that could limit its utility.
Conflicts
- risk increases when combined with other problematic ingredients
Safety
Safety Profile
Regulatory safety data from CIR, SCCS, and FDA for the SH-Oligopeptide-1 component is unavailable. While authorized for general cosmetic use at various concentrations, its long-term safety profile remains undefined. As a growth factor, there is a theoretical potential for tumorigenesis if cellular pathways are overexpressed or dysregulated; however, expert consensus suggests it is mitogenic (stimulates cell proliferation) but not mutagenic (does not induce cancerous changes). Specifically, OLIGOPEPTIDE-179 SH-OLIGOPEPTIDE-1 SP carries a likelihood of inducing irritation, inflammation, and dryness.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Given the insufficient comprehensive safety and clinical efficacy data, coupled with an identified moderate risk of irritation for this specific ingredient, its inclusion in formulations is currently questionable and requires further investigation.
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