Science
Mechanism of Action
This oligopeptide functions by improving the skin's tolerance to various external factors, including promoting melanocyte tolerance, which contributes to overall skin health. It also actively supports the skin's barrier function to prevent transepidermal water loss and maintain hydration.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Specific stability data for Oligopeptide-143 is unavailable. However, based on other oligopeptides, it is generally sensitive to pH, suggesting that formulations should ideally be adjusted to a pH range of 5-8 before its diluted addition. To preserve activity and prevent enzymatic decomposition, avoiding microbial contamination during processing is crucial. Incorporating the ingredient at the final stage of formulation at temperatures between 35-40 °C may also be beneficial.
Safety
Safety Profile
Comprehensive safety assessments for Oligopeptide-143 by regulatory bodies such as CIR, SCCS, or FDA have not been specifically identified. While the CIR Expert Panel broadly reviews tissue-derived proteins and peptides, specific data for Oligopeptide-143 is currently lacking. Related ingredients like sh-oligopeptide-1 (EGF) are authorized for cosmetic use but are noted to have unknown long-term risks.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While exhibiting a promising mechanism for skin conditioning, the current lack of specific clinical studies and comprehensive safety data necessitates further targeted research for Oligopeptide-143.
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References
Sources