Science
Mechanism of Action
This synthetic peptide, derived from osteopontin, operates by directly engaging key biological processes within and around the hair follicle. It stimulates hair growth through activating stem cells, promoting new blood vessel formation, and supporting the surrounding tissue. Its action involves targeting specific receptors such as neuropilin-1 (NRP-1) to enhance overall hair follicle function.
Research
Clinical Evidence
Medium-high confidence0.5%
Key findings
- 01 Clinical trials demonstrated that concentrations ranging from 0.5% to 1.5% led to a notable increase in hair density, averaging approximately 7 to 12 new hairs per cm² after four months of consistent use.
- 02 A 0.5% concentration specifically showed an average increase of ~12 hairs/cm² from baseline after four months, a result reported as comparable to established treatments like Finasteride.
- 03 Over 70% of users responded positively to treatment, observed with a once-daily application.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
No specific safety assessments by organizations such as CIR, SCCS, or FDA for Oligopeptide-128 or its sh-Oligopeptide-128 SP variant were identified in the available research. However, clinical trials noted good safety and tolerability.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Oligopeptide-128 is a valuable active ingredient demonstrating robust clinical efficacy in promoting hair growth and density, making it highly suitable for targeted hair loss treatments, pending further extensive safety reviews.
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References
Sources