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Moumoujus

OLIGOPEPTIDE-127 RH-OLIGOPEPTIDE-1.

Questionable / SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

OLIGOPEPTIDE-127 RH-OLIGOPEPTIDE-1 is a sophisticated bioengineered peptide, commonly identified as Epidermal Growth Factor (EGF), serving as a potent cell-communicating agent. It meticulously mimics the skin's natural growth factors to accelerate cellular regeneration and repair, fostering comprehensive skin revitalization and anti-aging benefits.

Summary

Cell-communicating ingredient Skin conditioning Emollient Accelerates skin cell growth and regeneration Boosts collagen production Enhances skin elasticity Improves skin barrier function Aids in wound healing Helps retain moisture Exhibits anti-inflammatory effects Reduces fine lines and wrinkles Refines skin texture and pore size Evens skin tone and addresses dyschromatic conditions

Science

Mechanism of Action

This advanced ingredient operates by directly signaling to various skin cells, including epidermal cells, keratinocytes, endothelial cells, and fibroblasts, to stimulate their proliferation. This orchestrated cellular growth and regeneration lead to an accelerated increase in natural collagen production, significantly enhancing skin elasticity and improving overall skin barrier function. Beyond its regenerative actions, OLIGOPEPTIDE-127 RH-OLIGOPEPTIDE-1 contributes to efficient wound healing, aids in optimal moisture retention, and exhibits anti-inflammatory properties, culminating in skin that is noticeably smoother, firmer, and deeply hydrated.

Research

Clinical Evidence

High confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Clinical evaluations documented statistically significant improvements in the appearance of fine lines, skin texture, pore size, and various dyschromatic conditions within the initial month of use of a serum containing barley bioengineered EGF, with continuous improvement noted over a 3-month study period.
  2. 02 A systematic review conducted in 2021 indicated that EGF possesses the capacity to accelerate wound healing across both medical and aesthetic applications.
  3. 03 In a study evaluating melasma reduction, 73% of subjects who applied a topical EGF serum twice daily for 8 weeks observed a decrease in their melasma without reporting adverse effects.
  4. 04 A clinical investigation involving 20 subjects demonstrated a 33.5% reduction in inflammatory acne lesions after six weeks of EGF cream application to one half of the face.
  5. 05 Several clinical trials have confirmed the effectiveness of sh-Oligopeptide-1 in promoting wound healing for diabetic patients following laser treatments and in managing conditions like Senile purpura.

Transparency

Dusting Analysis

Not commonly dusted

Specific effective concentrations for OLIGOPEPTIDE-127 RH-OLIGOPEPTIDE-1 are not delineated in the available research, making it difficult to establish a dusting threshold or identify common dusting practices.

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 8
0 7 14

Stability

Oligopeptide-1 demonstrates high sensitivity to pH fluctuations, necessitating the precise adjustment of a cream's pH to within the 5.0-8.0 range prior to the incorporation of any diluted EGF solution. Furthermore, it is susceptible to degradation by enzymes produced by microorganisms, underscoring the critical importance of preventing microbial contamination during all stages of product processing to maintain ingredient stability and efficacy.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

While Oligopeptide-1 (sh-Oligopeptide-1/EGF) is not currently identified on EWG's Restricted or Unacceptable Lists and was recognized in IECIC 2015 as a commonly utilized skin-conditioning agent, specific CIR safety assessments for 'OLIGOPEPTIDE-127 RH-OLIGOPEPTIDE-1' are not readily available. It is important to distinguish that active EGF is considered a potent unauthorized drug, whereas sh-EGF (sh-oligopeptide-1) is authorized for general cosmetic use in various concentrations, though its long-term risks remain largely unknown. EGF is mitogenic, meaning it stimulates cell proliferation, but is not mutagenic. However, significant caution is advised for individuals with pre-existing cancerous cells, a high number of moles, a history of excessive UV exposure, or other skin cancer risk factors, as EGF could potentially contribute to the proliferation of existing malignant cells. Additionally, it is not recommended for individuals with psoriasis. The use of high-purity ingredients is crucial to minimize the risk of irritation stemming from impurities.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

OLIGOPEPTIDE-127 RH-OLIGOPEPTIDE-1 demonstrates substantial potential for skin regeneration, anti-aging, and repair; however, due to insufficient specific safety data for this particular ingredient and critical warnings regarding its mitogenic activity for individuals with certain health conditions, its inclusion warrants meticulous consideration and, ideally, professional dermatological guidance.

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