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OLIGOPEPTIDE-126 SH-OLIGOPEPTIDE-1.

Questionable / HUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

OLIGOPEPTIDE-126 SH-OLIGOPEPTIDE-1, identified as Epidermal Growth Factor (EGF) or SH-Oligopeptide-1, is a potent signaling peptide designed to stimulate epidermal cell proliferation and differentiation. This ingredient actively promotes comprehensive skin regeneration, repair, and overall dermal renewal.

Summary

Promotes skin regeneration Supports anti-aging processes Reduces the appearance of fine lines and wrinkles Improves skin texture and smoothness Enhances skin firmness and elasticity Stimulates collagen synthesis Boosts elastin production Promotes a more even skin tone Minimizes pigmentation irregularities Reduces the visible size of pores Supports wound healing Provides anti-inflammatory benefits Helps reduce inflammatory acne lesions Contributes to long-term skin moisturization Improves skin barrier function Promotes scalp health Strengthens hair follicles Supports hair root regeneration

Science

Mechanism of Action

This peptide functions by precisely binding to EGF receptors present on various skin cell surfaces, including keratinocytes, endothelial cells, and fibroblasts. This interaction initiates a cascade of cellular activities, enhancing cell turnover, stimulating the synthesis of crucial extracellular matrix components such as collagen and elastin, and boosting glycosaminoglycan production. Consequently, it supports improved skin barrier function, mitigates inflammatory responses, accelerates the repair of damaged skin, and provides long-term moisturization, leading to a refined complexion and reduced scar visibility.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A 2012 study utilizing a barley bioengineered epidermal growth factor serum demonstrated statistically significant improvements in the appearance of fine lines, rhytids, skin texture, pore size, and various dyschromatic conditions within the initial month of use, with sustained enhancement observed over a three-month period.
  2. 02 One study reported a 73% reduction in melasma for subjects applying a topical EGF serum twice daily over eight weeks, with no reported side effects.
  3. 03 In a controlled study involving 20 subjects, an EGF cream applied to one half of the face for six weeks resulted in a 33.5% reduction in inflammatory acne lesions on the treated side compared to a vehicle control.
  4. 04 Multiple clinical trials have indicated sh-Oligopeptide-1's effectiveness in promoting wound healing in diabetic patients following laser treatment and aiding in the management of Senile purpura.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 8
0 7 14

Stability

OLIGOPEPTIDE-126 SH-OLIGOPEPTIDE-1 exhibits high sensitivity to pH, requiring the formulation's pH to be adjusted to a range of 5.0-8.0 before its incorporation. Preventing microbial contamination during processing is crucial, as microbial enzymes can lead to its decomposition. Due to its medium-sized and polar nature, specialized delivery systems such as liposomes may be necessary to ensure optimal skin penetration and efficacy.

Safety

Safety Profile

CIR Status
Unknown
Sensitization risk Unknown

Safety data from regulatory bodies like CIR, SCCS, and FDA is generally unavailable. While experts largely agree that EGF (SH-Oligopeptide-1) is mitogenic (stimulates cell proliferation) but not mutagenic (does not cause cancerous cell alterations), there is a critical concern that it could facilitate the spread of *existing* cancerous cells. Therefore, caution is advised for individuals with numerous moles, a history of excessive UV exposure, recognized skin cancer risk factors, or conditions like psoriasis, due to its ability to stimulate epidermal cell growth. A critical review further highlights a lack of proven preclinical bioactivity for topical sh-oligopeptide-1 and underscores unknown long-term risks despite its authorization for cosmetic use.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Questionable

OLIGOPEPTIDE-126 SH-OLIGOPEPTIDE-1 demonstrates significant potential for skin regeneration and anti-aging benefits in short-term studies; however, its inherent mitogenic activity and explicitly unknown long-term safety profile, particularly for individuals with elevated skin cancer risk or existing lesions, necessitate a highly cautious and considered application.

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