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Moumoujus

OLIGOPEPTIDE-123 RH-POLYPEPTIDE-7.

Avoid / SKIN CONDITIONING

OLIGOPEPTIDE-123 RH-POLYPEPTIDE-7 is a sophisticated, single-chain synthetic fusion peptide engineered via E. coli fermentation. It combines structural elements akin to human somatotropin (rh-Polypeptide-7) and a human collagen alpha-1 (iii) chain (Oligopeptide-123), designed primarily for skin conditioning.

Summary

Skin conditioning Collagen booster Elastin booster Hydration enhancer Skin elasticity improver Texture refiner Antiseborrhoeic Skin protecting Cell proliferation stimulant

Science

Mechanism of Action

This peptide is theorized to support the skin's natural renewal and repair processes by stimulating collagen and elastin production. Its constituent parts may contribute to enhanced skin structure, provide antiseborrhoeic and protective functions, and generally boost cell proliferation and hyaluronic acid levels, aiming to reduce wrinkles, improve elasticity, hydration, and overall skin texture.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH 5 – 8
0 7 14

Stability

The stability of this peptide, particularly its Oligopeptide-1 component, is highly sensitive to pH fluctuations and enzymatic degradation. Maintaining a product pH within the 5.0 to 8.0 range is critical, and rigorous measures to prevent microbial contamination during processing are essential to preserve its integrity and usefulness.

Conflicts

  • Prohibited for use in cosmetic products within the European Union (Restriction II/416).
  • Potential to increase irritation risk when combined with other known problematic ingredients.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

OLIGOPEPTIDE-123 RH-POLYPEPTIDE-7 is explicitly PROHIBITED for use in cosmetic products in the EU under Restriction II/416. There is a general likelihood of irritation, and this risk increases when formulated with other problematic ingredients. Individuals, especially those with sensitive skin, may experience allergic reactions or sensitivities such as redness, itching, or rashes. Long-term safety data, even for related authorized peptides, often remains largely undefined.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Due to its prohibition in the EU and the absence of robust, independently verified clinical studies to substantiate its claimed benefits, OLIGOPEPTIDE-123 RH-POLYPEPTIDE-7 is an ingredient Moumoujus would advise against incorporating into skincare formulations.

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