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OLIGOPEPTIDE-123 RH-OLIGOPEPTIDE-1.

Valuable / SKIN CONDITIONING

OLIGOPEPTIDE-123 RH-OLIGOPEPTIDE-1, also known as Epidermal Growth Factor (EGF), is a potent cell-communicating peptide that stimulates skin cell growth and regeneration. It functions as a skin conditioning agent, promoting repair processes to enhance overall skin health and appearance.

Summary

cell-communicating ingredient skin conditioning wound healing skin renewal stimulates cell growth promotes proliferation enhances hydration strengthens skin barrier anti-inflammatory

Science

Mechanism of Action

This peptide acts as a biomimetic signal, activating the skin's intrinsic repair mechanisms and directly fostering the proliferation of epidermal cells. It significantly boosts the synthesis of crucial extracellular matrix components, including collagen, elastin, and hyaluronic acid, leading to improved skin firmness and elasticity. Furthermore, it strengthens the skin's natural barrier function, augments moisture retention, and mitigates inflammatory responses, thereby reducing redness and soothing irritation.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 8
0 7 14

Stability

OLIGOPEPTIDE-123 RH-OLIGOPEPTIDE-1 exhibits high sensitivity to pH; formulations should be adjusted to a pH range of 5-8 before its inclusion. To preserve activity, it must be protected from microbial contamination during processing and incorporated into cosmetic formulations at temperatures below 40℃ during the final manufacturing stage.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) has not specifically evaluated OLIGOPEPTIDE-123 RH-OLIGOPEPTIDE-1. While sh-EGF forms are authorized for cosmetic use, long-term risks remain undefined. Though generally considered mitogenic (cell-stimulating) rather than mutagenic (cell-altering), concerns exist regarding its classification as a 'growth factor' due to EGF signaling in tumor cells. However, it is not listed on EWG's restricted lists and is not deemed carcinogenic. High-purity, biotechnologically produced ingredients may minimize irritation risks.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

OLIGOPEPTIDE-123 RH-OLIGOPEPTIDE-1 is a valuable active ingredient for comprehensive skin rejuvenation, promoting cellular renewal, enhancing hydration, and improving overall skin structure.

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