Science
Mechanism of Action
This oligopeptide acts primarily as a skin conditioning agent. Generally, oligopeptides stimulate the endogenous production of collagen and elastin, critical proteins for maintaining skin structure and firmness. They are also understood to possess moisturizing capabilities and can penetrate skin layers to influence cellular regeneration. Specific examples, like Oligopeptide-1, are known to promote epidermal cell growth and slow age-related skin thinning, while Oligopeptide-24 enhances skin cell proliferation by up-regulating Epidermal Growth Factor (EGF) expression, mimicking essential components for renewing epidermal and dermal cells, hyaluronic acid, collagen, elastin, and fibronectin.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
While specific stability data for Oligopeptide-117 is not available, related oligopeptides like Oligopeptide-1 are highly sensitive to pH and susceptible to enzymatic degradation by microorganisms, which can lead to activity loss. Therefore, minimizing microbial contamination during processing and adjusting product pH to between 5 and 8 before incorporating diluted peptide solutions are crucial. Some oligopeptides exhibit conformational and thermal stability within a near-neutral pH range (20-90°C).
Safety
Safety Profile
Oligopeptide-117 currently lacks a thorough safety review by major regulatory bodies like CIR or SCCS, and is 'Not rated' by Paula's Choice. While specific assessments are absent for this peptide, related sh-oligopeptide-1 (EGF) is authorized for cosmetic use in various concentrations, though its long-term systemic risks are not fully understood. It is important to note that active EGF is categorized as an unauthorized drug for medical treatments.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Oligopeptide-117 shows promise based on the established benefits of other oligopeptides for skin conditioning and rejuvenation, yet specific clinical efficacy, optimal usage concentrations, and comprehensive safety data for this particular peptide are currently limited.
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