Science
Mechanism of Action
This oligopeptide acts as a vital signaling molecule within the skin, initiating a cascade of beneficial cellular responses. It is recognized for its capacity to stimulate the biosynthesis of critical structural proteins, specifically collagen and elastin, which are essential for maintaining dermal integrity and resilience. Beyond structural support, it exhibits potent humectant properties, drawing and retaining moisture to significantly enhance skin hydration and luminosity. Furthermore, Oligopeptide-114 Acetate contributes to advanced skin repair and regeneration by fostering accelerated healing and promoting optimal cell turnover, refining overall skin texture. Certain oligopeptides, by extension, demonstrate antioxidant capabilities through free radical neutralization and can help regulate melanin synthesis to address hyperpigmentation.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Oligopeptide-114 Acetate, or closely related P11-4 acetate, has shown insolubility in both water and DMSO, suggesting the necessity of specialized co-solvents such as PEG300/400, Tween 80, or corn oil for successful dissolution. Peptides are generally sensitive to environmental stressors like freezing, excessive heat, and agitation, which can induce aggregation. Optimal stability is typically observed within a slightly acidic pH range of 3.0 to 6.0, with specific reports indicating best stability for related peptides between pH 3 and 5 to minimize deamidation, and for leuprolide acetate between pH 4 and 6. However, at lower pH, related peptides like P11-4 can self-assemble into β-sheet amyloids, necessitating careful pH management.
Safety
Safety Profile
Oligopeptide-114 Acetate lacks specific safety assessments from regulatory bodies such as CIR, SCCS, or FDA. While general evaluations for other oligopeptides by CIR have noted the potential for Type I immediate hypersensitivity reactions, no such specific data is available for Oligopeptide-114 Acetate. It is not rated by Paula's Choice, indicating a limited public safety research profile.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Oligopeptide-114 Acetate presents compelling theoretical benefits for anti-aging, hydration, and skin repair based on general oligopeptide mechanisms, yet specific clinical efficacy and safety data for this particular compound are currently limited, warranting further research for precise application.
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