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OLIGOPEPTIDE-10.

Valuable CAS - / ANTIMICROBIAL, DEODORANT, SKIN CONDITIONING

Oligopeptide-10 is a sophisticated 15-amino-acid peptide designed to precisely combat acne-causing bacteria and mitigate inflammatory responses. It employs a mechanical mode of action to disrupt bacterial integrity, reducing the appearance of blemishes and redness without fostering antibiotic resistance. This ingredient also supports the skin's natural defense mechanisms.

Summary

Antimicrobial/antibacterial Anti-inflammatory Skin-identical ingredient Antioxidant Cell-communicating ingredient Collagen and Elastin stimulation

Science

Mechanism of Action

This 15-amino-acid peptide exhibits broad-spectrum bactericidal action, particularly against Gram-positive Cutibacterium acnes. Its multiple positive charges are attracted to the negatively charged bacterial cell membrane, specifically binding to lipoteichoic acids. This interaction physically disrupts the bacterial cytoplasmic membrane, leading to osmotic imbalance and rapid cell death. This mechanical process prevents bacteria from developing resistance. Furthermore, Oligopeptide-10 neutralizes pro-inflammatory bacterial components, thereby reducing redness and irritation. It also enhances the skin's inherent defense by stimulating antimicrobial peptide production and possesses intrinsic anti-inflammatory properties. Some research additionally indicates its ability to stimulate collagen and elastin production and function as an antioxidant.

Research

Clinical Evidence

Medium confidence
Effective range 0.001–0.01%
Optimal

N/A

Key findings

  1. 01 Independent studies and supplier data consistently demonstrate a significant reduction in the appearance of blemishes and red, blotchy spots within concentrations ranging from 0.001% to 0.01%.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 7
0 7 14

Stability

Compatible with all emulsion systems. It should be incorporated into the water phase during the final manufacturing stage, with process temperatures maintained below 45 °C, ideally 40 °C, to preserve peptide integrity and stability.

Synergies

  • salicylic acid
  • other anti-acne ingredients

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Oligopeptide-10 is considered a safe ingredient for skincare, demonstrating a low toxicity, irritation, and sensitization profile. Independent studies confirm it to be non-cytotoxic, non-mutagenic, non-irritating, and non-sensitizing. SkinSAFE further lists it as 'Irritant Free'.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Oligopeptide-10 is a valuable peptide for precision skincare, effectively combating acne-causing bacteria and inflammation through a non-resistance-inducing mechanism, while also offering restorative and protective benefits for a range of skin types.

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