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Moumoujus

OLEOYL DIPEPTIDE-15.

Valuable CAS 244608-20-6 / SKIN CONDITIONING

Oleoyl Dipeptide-15 is a synthetic lipopeptide engineered to combat intrinsic chronological skin aging. It precisely targets the degradation of collagen and elastin, while promoting cellular functions vital for maintaining skin structure and resilience.

Summary

Skin conditioning Anti-aging Reduces glycation Improves skin elasticity Supports extracellular matrix integrity Reduces fine lines and wrinkles

Science

Mechanism of Action

This synthetic lipopeptide precisely addresses chronological skin aging by targeting two critical processes: protein glycation and elastosis. It demonstrably reduces collagen type 1 glycation by up to 60% and acts as a potent inhibitor of MMP-12, a metalloproteinase responsible for elastin breakdown, showing a 58% inhibition rate. Furthermore, Oleoyl Dipeptide-15 restores Fibrillin-1 expression, which is often suppressed by glycation, thereby enhancing fibroblast metabolism, improving fibril organization, and promoting tissue retraction by up to 50%. Its comprehensive action supports the integrity and organization of the extracellular matrix.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

0.1%

Key findings

  1. 01 In a clinical trial, a dermocosmetic formulation containing 0.1% Oleoyl Dipeptide-15, in combination with 0.1% Retinal and 0.1% Delta-Tocopherol Glucoside, significantly improved visible signs of naturally aged skin, including periocular fine lines and crow's feet, after 2 months of daily application.
  2. 02 In vitro studies indicate a reduction in collagen type 1 glycation by up to 60%.
  3. 03 In vitro data shows a 58% inhibition of MMP-12, a metalloproteinase involved in elastin degradation, demonstrating greater efficacy than its precursor, Dipeptide-15 (10% inhibition).
  4. 04 In vitro results demonstrate restoration of Fibrillin-1 expression, which is suppressed by glycation, thereby promoting fibroblast metabolism, fibril organization, and tissue retraction by up to 50%.

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
0.1%

A clinical study demonstrated significant improvements in visible signs of aging with a formulation containing 0.1% Oleoyl Dipeptide-15 in combination with other actives. While its precise standalone effective minimum is not established, concentrations significantly below this 0.1% may be considered insufficient to deliver noticeable benefits.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

For optimal stability, Oleoyl Dipeptide-15 should be stored in a well-ventilated, dry place at 2-8 °C, protected from direct sunlight. For long-term preservation, storage under -20 °C with the container tightly closed is recommended.

Synergies

  • Retinal
  • Delta-Tocopherol Glucoside

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While the Cosmetic Ingredient Review (CIR) Expert Panel has broadly reviewed peptides, Oleoyl Dipeptide-15 specifically has not undergone an individual safety assessment. No specific SCCS or FDA status is currently available, but it is generally regarded as having a low irritancy potential.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Oleoyl Dipeptide-15 is a valuable lipopeptide for comprehensive anti-aging skincare, demonstrably improving visible signs of aging by targeting glycation and elastosis, with favorable skin compatibility across all skin types.

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