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OENOTHERA BIENNIS FLOWER/LEAF/STEM EXTRACT.

Valuable CAS 90028-66-3 / SKIN CONDITIONING

Oenothera Biennis Flower/Leaf/Stem Extract, derived from Evening Primrose, is a potent botanical ingredient acclaimed for its comprehensive benefits in skincare. It delivers robust antioxidant and anti-inflammatory actions, enhances skin barrier function, provides deep moisturization, and offers significant anti-aging and sebum-regulating properties.

Summary

Antioxidant Anti-inflammatory Skin Conditioning Skin Protecting Soothing Anti-aging Moisturizing Astringent Barrier Enhancement Sebum Regulation

Science

Mechanism of Action

This extract operates through sophisticated cellular pathways. It exhibits antioxidant properties by neutralizing reactive oxygen species (ROS) and activating the Nrf2/HO-1 signaling pathway, thereby protecting cells from oxidative stress. Its anti-inflammatory capabilities stem from reducing key mediators such as nitric oxide (NO), prostaglandin E2 (PGE2), interleukin 1β (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor α (TNF-α). For moisturization, it significantly improves hyaluronic acid (HA) production and upregulates moisturizing genes like hyaluronic acid synthase 2 (HAS2) and aquaporin 3 (AQP3). Skin barrier integrity is enhanced by recovering *Staphylococcus aureus*-induced downregulation of filaggrin (FLG) expression and optimizing the skin's lipid barrier. Anti-aging effects are mediated by promoting matrix collagen contraction, actin polymerization, and the production of extracellular matrix (ECM) proteins via increased MYLK gene expression. It also contributes to anti-wrinkle activity by inhibiting matrix metalloproteinases-1 and -2 and boosting type I collagen production. Furthermore, it regulates sebum by effectively inhibiting palmitic acid-induced sebum in sebocytes.

Research

Clinical Evidence

High confidence
Effective range 5–10%
Optimal

N/A

Key findings

  1. 01 Clinical studies recommend an optimal use level of 5-10% for a raw material standardized to a 20% extract concentration, demonstrating significant antioxidant and anti-inflammatory properties crucial for anti-aging and soothing applications.
  2. 02 Research involving a 70% ethanol extract (raw material) revealed broad efficacy, including skin soothing, antioxidant activity, barrier enhancement, moisturization, anti-inflammatory effects (reducing nitric oxide and prostaglandin E2), and sebum control.
  3. 03 An *in vitro* assessment at 60 µg/mL exhibited significant antiproliferative and pro-apoptotic activity against the A375 human melanoma cell line.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Oenothera Biennis Flower/Leaf/Stem Extract is clinically proven safe, generally well-tolerated, and non-allergenic, with a good safety profile and low irritancy. However, individuals with known plant allergies are advised to perform a patch test. While the CIR Expert Panel has deemed Oenothera Biennis (Evening Primrose) Oil safe for cosmetic use, the specific Flower/Leaf/Stem Extract has not undergone an independent CIR review. Its use is permitted in cosmetic products under regulatory guidelines, advising adherence to recommended concentrations.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

OENOTHERA BIENNIS FLOWER/LEAF/STEM EXTRACT is a valuable botanical ingredient, offering comprehensive benefits from robust antioxidant and anti-inflammatory protection to enhanced moisturization, barrier repair, anti-aging effects, and sebum regulation, suitable for all skin types.

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