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Moumoujus

OCTAPEPTIDE-31.

Valuable / SKIN CONDITIONING

Octapeptide-31, also identified as Acetyl Octapeptide-3 or SNAP-8, is a sophisticated biomimetic peptide designed to specifically target and diminish dynamic expression lines. It functions by temporarily modulating facial muscle contractions, leading to a noticeable smoothing of the skin's surface and a reduction in wrinkle appearance.

Summary

Anti-aging Skin-Conditioning Moisturizer/Humectant

Science

Mechanism of Action

This peptide operates by mimicking the activity of the neurotransmitter acetylcholine, which is pivotal for muscle contraction. Octapeptide-31 precisely competes for specific binding sites within the SNARE complex, a critical protein assembly involved in neurotransmitter release. By antagonistically reducing SNARE complex activity, it effectively inhibits facial muscle contraction, resulting in a visible relaxation of the skin and a smoother appearance of wrinkles and fine lines, without inducing muscle paralysis.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

0.005%

Key findings

  1. 01 In a study involving 17 women, a solution containing 0.005% pure Octapeptide-31 (as part of a 10% SNAP-8 solution) demonstrated a significant 34.98% reduction in wrinkle depth over 28 days with twice-daily application. This performance notably surpassed a 10% Argireline solution, which achieved a 27.05% reduction under identical conditions.
  2. 02 Consistent daily application of products formulated with Acetyl Octapeptide-3 has been shown to visibly diminish wrinkles around the eyes and mouth within as little as 28 days.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

While a precise optimal pH range for Acetyl Octapeptide-3 stability has not been definitively established, peptides generally exhibit varied stability profiles depending on their specific structure. This ingredient is readily incorporated into both emulsions and serum formulations, suggesting good general stability.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Specific safety assessments by regulatory bodies such as CIR, SCCS, or FDA for Acetyl Octapeptide-3 (SNAP-8) are currently not available. However, it is broadly regarded as a safer topical alternative to Botulinum Toxin for wrinkle reduction.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Octapeptide-31 is a valuable peptide for precision skincare, effectively targeting and reducing the appearance of dynamic wrinkles by safely inhibiting facial muscle contractions.

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