Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

OCTAPEPTIDE-13.

Valuable / SKIN CONDITIONING

OCTAPEPTIDE-13, also known as Acetyl Octapeptide-3 or SNAP-8, is a biomimetic peptide specifically engineered to target expression lines. It functions as a 'Botox-like' ingredient by modulating muscle contractions, while concurrently enhancing skin hydration and elasticity.

Summary

Neuromodulator Anti-aging Wrinkle Reducer Skin Firming Humectant Antioxidant Cell-communicating ingredient

Science

Mechanism of Action

OCTAPEPTIDE-13 operates as a neuromodulating peptide by interfering with the SNARE complex, a critical protein involved in muscle stimulation. It mimics the N-terminal end of the SNAP-25 protein, competitively binding to the SNARE complex to destabilize it. This action reduces neuronal excitability and inhibits the release of neurotransmitters, such as adrenaline, that cause facial muscle contractions, leading to muscle relaxation and a visible reduction in the depth of fine lines and expression wrinkles, particularly on the forehead and around the eyes. Furthermore, it supports the generation of collagen and elastin for smoother skin, enhances moisture retention through its water-binding capacity, and provides antioxidant protection.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The provided research data does not indicate that OCTAPEPTIDE-13 is an ingredient commonly associated with cosmetic dusting, nor does it specify any dusting thresholds or red flag percentages.

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 7
0 7 14

Stability

For optimal stability and integrity, OCTAPEPTIDE-13 should be incorporated into the aqueous phase of formulations at temperatures below 40°C during the cool-down phase. The ideal pH range for formulations is between 5.0 and 7.0. Raw material storage requires freezing at -15°C to -20°C, protected from light and air, to ensure a 24-month shelf life, as the ingredient is hygroscopic. Recommended usage rate in formulations is 1-5%.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While formal CIR or SCCS safety assessments are not readily available, OCTAPEPTIDE-13 is generally regarded as a well-tolerated, milder, and non-toxic alternative to botulinum toxin. It is often marketed as 'Irritant Free', though very sensitive individuals are advised to perform patch testing due to rare instances of mild irritation. Hazard statements (e.g., H302: Harmful if swallowed) apply solely to the undiluted chemical form and not to its diluted use in cosmetic products.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

OCTAPEPTIDE-13 is a valuable neuromodulating peptide for effectively addressing expression lines and wrinkles, offering 'Botox-like' effects alongside skin hydration and anti-aging benefits with a low sensitization risk.

Related

Similar Ingredients

Finding similar ingredients…