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OCTAHYDRO-TETRAMETHYLCYCLOPROPANAPHTHALENONE.

Avoid CAS 25966-79-4 / PERFUMING

Octahydro-Tetramethylcyclopropanaphthalene, frequently identified as Iso E Super or Tetramethyl Acetyloctahydronaphthalenes, is a synthetic aromatic compound. Its primary function in formulations is to impart a desired scent or mask undesirable odors, alongside offering skin conditioning benefits.

perfuming masking skin conditioning

Science

This ingredient operates by enhancing the olfactory profile of a product or the skin through its perfuming action. Additionally, it contributes to skin conditioning, aiming to improve the appearance of dry or compromised skin by reducing flaking and promoting a more supple texture.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

This compound demonstrates high stability, exhibiting very good to good performance and integrity across diverse applications such as shampoos, soaps, antiperspirant deodorants, and fine fragrances. Its oil solubility is quantitatively supported by a log P (octanol-water partition coefficient) value between 5.65 and 5.7, and a low water solubility of 2.68 mg/L at 20°C.


Safety

CIR Status
Safe with restrictions
Sensitization risk High

Under European Union regulations, this ingredient is subject to restrictions as per Annex III of the EC Cosmetics Regulation, following an assessment by the SCCS, and is formally identified as a known allergen. The International Fragrance Association (IFRA) established safe use levels for consumer products effective August 2009. A 13-week repeat dose toxicity study conducted by the U.S. National Toxicology Program (NTP) in 2014 reported no adverse effects, with genetic toxicity studies predominantly negative.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Medium
Comedogenicity Unknown

Our Assessment

Avoid

While providing perfuming and skin conditioning properties, its designation as a known allergen by the EU and its medium irritancy profile present significant concerns, leading to an 'avoid' recommendation for precision skincare formulations.


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