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OCTAFLUOROPENTYL METHACRYLATE.

Avoid CAS 355-93-1 / BINDING

Octafluoropentyl Methacrylate is a synthetic compound known for its ability to create a water-repelling barrier on skin and hair, imparting hydrophobic properties and enhancing product texture. However, its use is associated with significant safety concerns, including potential toxicity and environmental persistence.

Summary

Forms protective barrier Improves texture Antimicrobial agent Antibiofilm agent Protein repellent

Science

Mechanism of Action

This ingredient functions by forming a low surface energy, hydrophobic film on the skin or hair, effectively repelling water and preventing moisture damage. It can also contribute to a smoother, more spreadable product texture. Preliminary studies suggest potential antimicrobial, antibiofilm, and protein-repellent activities.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

The chemical is stable under typical storage conditions but contains a reactive acrylic group susceptible to polymerization, necessitating the inclusion of polymerization inhibitors like MEHQ or TBC. It must be protected from heat, sparks, open flames, and other ignition sources, and stored in a cool, well-ventilated area. Acidic monomers may react adversely with basic initiators, preventing polymerization.

Conflicts

  • Basic initiators (if acidic monomers are present)
  • Heat
  • Sparks
  • Open flames
  • Ignition sources

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
5%
Sensitization risk High

The CIR Expert Panel considers methacrylate ester monomers, including this ingredient, safe for use in nail enhancement products provided skin contact is strictly avoided due to their sensitizing potential. The ingredient is identified as an irritant. EWG classifies Octafluoropentyl Methacrylate as a PFAS compound, raising high concerns regarding enhanced skin absorption, use restrictions, environmental persistence, and bioaccumulation. Furthermore, EWG highlights moderate concerns for endocrine disruption and non-reproductive organ system toxicity, and notes it as a possible human carcinogen, a known human reproductive or developmental toxin, and a known human immune toxicant or allergen.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Despite its functional benefits in barrier formation and texture enhancement, Octafluoropentyl Methacrylate presents severe safety risks, including classification as a PFAS compound, potential carcinogenicity, reproductive toxicity, high irritancy and sensitization potential, rendering it unsuitable for precision skincare formulations.

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