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Moumoujus

OCIMUM GRATISSIMUM HERB EXTRACT.

Valuable CAS 91770-38-6 / PERFUMING

Ocimum Gratissimum Herb Extract, derived from African basil, is a botanical ingredient recognized for its multifaceted benefits in skincare. Rich in key compounds like eugenol and thymol, it offers targeted antimicrobial, anti-inflammatory, and antioxidant properties, making it particularly beneficial for addressing specific skin concerns.

Summary

Antimicrobial Anti-inflammatory Antioxidant Perfuming Agent

Science

Mechanism of Action

This extract operates through a synergy of active compounds, predominantly eugenol and thymol, which are prominent in its essential oil. These constituents effectively disrupt bacterial and fungal cell structures, demonstrating potent antimicrobial and antifungal activity against a spectrum of pathogens including Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, and various dermatophytes. Concurrently, the extract aids in mitigating inflammatory responses and provides robust antioxidant defense, thereby protecting the skin from oxidative stress.

Research

Clinical Evidence

Medium confidence
Effective range 0.75 µg/mL (essential oil)–2% v/v (essential oil)%
Optimal

2% v/v (essential oil)

Key findings

  1. 01 Topical preparations containing 2% v/v of the essential oil demonstrated no skin irritation, while 5% v/v showed irritating effects unless formulated in a petrolatum base.
  2. 02 An ethanol extract at concentrations between 0.2-0.8 mg/mL exhibited antibacterial activity against Staphylococcus aureus.
  3. 03 An aqueous extract showed a minimum inhibitory concentration (MIC) of 0.2 mg/mL against Klebsiella pneumoniae.
  4. 04 The essential oil demonstrated MICs of 0.75 µg/mL against S. aureus and 6 µg/mL against E. coli.

Transparency

Dusting Analysis

Not commonly dusted

Information regarding common 'dusting' practices or specific dusting thresholds for Ocimum Gratissimum Herb Extract is not available in the provided research data.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The essential oil components are volatile, and their chemical composition can vary significantly due to genetic, environmental, and agronomic factors. Optimal extraction conditions for maximizing antioxidant properties may depend on temperature and solvent type.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
2% v/v (essential oil)%
Sensitization risk Moderate

Ocimum Gratissimum Herb Extract lacks specific review status from CIR, SCCS, or FDA as a cosmetic ingredient. General safety assessments (GHS Classification) indicate no specific hazard statements. However, topical application of the essential oil at 5% v/v has shown skin irritation, whereas 2% v/v was observed to be non-irritating in topical preparations not in a petrolatum base. This indicates a concentration-dependent irritation potential, advising careful formulation.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Ocimum Gratissimum Herb Extract offers valuable antimicrobial, anti-inflammatory, and antioxidant benefits, particularly for oily and normal skin, provided it is precisely formulated at concentrations below its identified irritation threshold.

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