Science
Mechanism of Action
This extract functions as a comprehensive skin conditioning agent. Its anti-inflammatory capabilities are primarily driven by the downregulation of NF-κB, a crucial pathway involved in inflammatory responses. Beyond this, it possesses inherent antimicrobial, antibacterial, and antioxidant properties, contributing to overall skin health and protection against environmental aggressors.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 In laboratory studies, ethanol extracts of Nuphar Luteum Root demonstrated effectiveness against bacterial strains at concentrations between 100-400 µg/mL and fungal strains at 100 µg/mL.
- 02 Methanol extracts also exhibited antibacterial activity from 200-800 µg/mL and antifungal effects at 100 µg/mL.
- 03 Additionally, potent antitrypanosomal activity was observed against Trypanosoma brucei, with an IC50 below 10 µg/mL and over 90% inhibition achieved at 20 µg/mL.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
No specific safety assessments from CIR, SCCS, or FDA have been published for Nuphar Luteum Root Extract in cosmetic use. While reported oral and dermal toxicity data is undetermined, major cosmetic ingredient databases indicate a low risk for irritancy and comedogenicity. Historical toxicity concerns relate to ingestion of high concentrations of whole plant material, which differs from its topical cosmetic application.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Nuphar Luteum Root Extract is a valuable botanical ingredient offering anti-inflammatory, antimicrobial, and antioxidant potential with low irritancy and comedogenicity, though further *in vivo* cosmetic efficacy and formal safety assessments are recommended.
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