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Ingredient directory

Nuphar Luteum Leaf

Nuphar Luteum Leaf extract, derived from the yellow water-lily, offers a multifunctional profile for skincare. Research indicates its potential in mitigating inflammation, exhibiting broad-spectrum antimicrobial activity against bacteria and fungi, and providing antioxidant benefits. This botanical ingredient is suited for formulations targeting various skin concerns, including those with sensitivity or imbalances.

Directory entry · Individual source review pending

This profile is awaiting an individual source review. Treat its ratings, dose estimates and compatibility labels as provisional; they are not medical advice or proof of a finished product’s effects.

skin conditioning emollient antimicrobial antioxidant anti-inflammatory

Science

Mechanism of Action

This ingredient operates via several distinct pathways to benefit the skin. It exhibits anti-inflammatory properties primarily by inhibiting the NF-κB pathway, which is crucial in inflammatory responses, and by modulating cytokine production, specifically reducing pro-inflammatory markers (TNF-α, IL-6, IL-12) while increasing the anti-inflammatory cytokine IL-10. Additionally, it influences ERK phosphorylation and demonstrates antioxidant capabilities. Its antimicrobial action encompasses both antibacterial and antifungal effects, contributing to a balanced skin microbiome.

Research

Clinical Evidence

Medium confidence
Effective range 100–800%
Optimal

N/A

Key findings

  1. 01 In vitro studies indicate effective antimicrobial activity, with ethanol extracts showing efficacy against bacterial strains between 100-400 µg/mL and fungal strains at 100 µg/mL. Methanol extracts were effective against bacterial strains from 200-800 µg/mL and fungal strains at 100 µg/mL.
  2. 02 In murine models of acute septic shock, a partially-purified extract significantly improved survival rates by 60% and reduced key pro-inflammatory cytokines (TNF-α, IL-6, IL-12) while increasing anti-inflammatory IL-10, demonstrating robust anti-inflammatory effects.
  3. 03 The active compound 6,6′-dihydroxythiobinupharidine (DTBN) derived from Nuphar lutea, administered at 25 µg in a mouse model of chronic kidney disease, ameliorated kidney damage and inflammation.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has not yet reviewed Nuphar Luteum Leaf extract for safety. However, current data suggests a low irritancy potential.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Nuphar Luteum Leaf shows promising *in vitro* and *in vivo* (murine) data for anti-inflammatory, antimicrobial, and antioxidant benefits, suggesting valuable potential for skin conditioning, particularly for oily, normal, and sensitive skin types, but requires further human topical studies for a definitive assessment.

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