Science
Mechanism of Action
Nuphar Lutea Extract exerts its anti-inflammatory effects by downregulating the NF-κB pathway, a critical regulator of inflammatory responses, and by modulating cytokine production, alongside influencing ERK phosphorylation. Beyond inflammation, it demonstrates comprehensive antimicrobial, antibacterial, antifungal, and antiviral capabilities, thus contributing to a balanced skin microbiome. Additionally, the extract is noted for supporting skin repair and regeneration, potentially aiding in the management of inflammatory skin conditions and promoting cellular health.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 Highly effective against Leishmania major promastigotes in vitro, with an IC50 of 2.0 +/- 0.12 µg/mL.
- 02 Achieved total elimination of intracellular Leishmania major parasites within 3 days at 1.25 µg/mL in vitro.
- 03 Demonstrated dose- and time-dependent reduction in proliferation and viability of human Acute Myeloid Leukemia (AML) cells (0.3–10 µg/mL) in vitro, inducing apoptosis.
Transparency
Dusting Analysis
Data for common dusting practices or specific red-flag percentages related to Nuphar Lutea Extract in cosmetic formulations is not available within the provided research.
The Formula
Formulation
Stability
Extracts are typically prepared using polar solvents such as methanol and water; acidified water has also been utilized as a solvent during extraction.
Safety
Safety Profile
No specific CIR or SCCS safety assessments are available, and FDA status for cosmetic use remains unknown. However, it is generally considered non-irritating, with minimal side effects noted in homeopathic contexts. INCI Beauty reports no penalties across categories for similar extracts, indicating a favorable safety profile.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Nuphar Lutea Extract is a valuable ingredient, demonstrating strong anti-inflammatory and broad antimicrobial mechanisms in vitro, though further human clinical studies are needed to substantiate direct cosmetic efficacy on skin.
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References
Sources