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Ingredient directory

Nonoxynol/nonyl Nonoxynol-49

NONOXYNOL/NONYL NONOXYNOL-49 functions as a non-ionic surfactant, instrumental in facilitating the blend of oil and water-based ingredients. It acts as an emulsifier, dispersant, and cleansing agent by reducing surface tension, which supports stable formulations and efficient removal of impurities from the skin.

Directory entry · Individual source review pending

This profile is awaiting an individual source review. Treat its ratings, dose estimates and compatibility labels as provisional; they are not medical advice or proof of a finished product’s effects.

Emulsifying Surfactant Cleansing Dispersant Foaming Agent

Science

Mechanism of Action

As a non-ionic surfactant, NONOXYNOL/NONYL NONOXYNOL-49 reduces the surface tension of water, thereby enabling oil and water components to mix and form stable emulsions. This action also aids in dispersing ingredients and effectively lifting dirt, oil, and other impurities from surfaces. It's noted that related nonoxynol compounds can interact with and lyse cell membranes.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

This ingredient demonstrates high chemical stability when exposed to oxidizing and reducing agents, as well as both acidic and alkaline conditions.

Conflicts

  • Potential for irritation and endocrine disruption due to residual nonylphenol
  • Environmental concerns regarding persistence and estrogenic activity

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
5%
Sensitization risk Moderate

The CIR Expert Panel considers Nonoxynols (including Nonoxynol-49) safe in cosmetics when formulated to be non-irritating, with a 5% limit for lower molecular weight nonoxynols (Nonoxynol-1 through -8) in leave-on products. However, NONOXYNOL/NONYL NONOXYNOL-49 and other nonoxynols are banned for use in cosmetics and personal care products within the European Union. Related compounds like Nonoxynol-9, used as a spermicide, carry FDA warnings for potential vaginal/rectal irritation and increased HIV risk. Concerns also exist regarding residual nonylphenol's potential for irritation and endocrine disruption, alongside environmental impact.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Despite its functional versatility as a surfactant and emulsifier, this ingredient is unsuitable for precision skincare due to its ban in the European Union, potential for irritation and endocrine disruption, and environmental concerns.

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