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Moumoujus

NONAPEPTIDE-8.

Valuable CAS - / SKIN CONDITIONING

NONAPEPTIDE-8, often researched under the name Nonapeptide-1 (Melanostatine-5), is a synthetic peptide primarily recognized for its potent skin brightening and anti-pigmentation properties. It is also believed to contribute to overall skin radiance and support collagen synthesis, addressing signs of aging.

Summary

Skin brightening Anti-pigmentation Antioxidant Collagen synthesis booster Anti-aging

Science

Mechanism of Action

Research indicates that Nonapeptide-1, associated with NONAPEPTIDE-8's reported benefits, functions as a competitive antagonist of the melanocortin 1 receptor (MC1R) on melanocytes. By binding to MC1R, it effectively blocks the action of alpha-melanocyte-stimulating hormone (α-MSH), which is crucial for melanin synthesis. This competitive action, along with direct inhibition of tyrosinase (a key enzyme in melanin production) and downregulation of MC1R, TRP1, TRP2, and MITF expression, leads to reduced pigmentation. Additionally, it is thought to stimulate collagen production, thereby improving skin elasticity and minimizing the appearance of fine lines.

Research

Clinical Evidence

Medium confidence
Effective range 0.01–5%
Optimal

0.5%

Key findings

  1. 01 Enhanced skin appearance, improved radiance, reduced dark spots.
  2. 02 Observable amelioration in melasma severity and melanin index.
  3. 03 Significant skin lightening and overall skin state improvement.

Transparency

Dusting Analysis

Not commonly dusted

Insufficient data available to determine if this ingredient is commonly 'dusted' in formulations.

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 7
0 7 14

Stability

For optimal stability, it is advisable to incorporate the peptide into formulations at temperatures below 45°C during the final stage of manufacturing. Peptides, including Nonapeptide-8, can exhibit distinct pH-dependent solubility characteristics.

Conflicts

  • Strong acids
  • Strong alkalis
  • Strong oxidizing agents
  • Acyl chlorides
  • Acid anhydrides
  • Formaldehyde-releasing preservatives

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Nonapeptide-1 (Melanostatine-5), the compound typically associated with the properties of NONAPEPTIDE-8, is generally considered safe for cosmetic applications, with a low incidence of irritation or adverse reactions. It is well-tolerated across various skin types, including sensitive skin, and is permitted by regulatory bodies such as the European Cosmetics Regulation. While no significant risks concerning cancer, reproductive toxicity, or immunotoxicity have been identified, patch testing is recommended for individuals with known sensitivities. The Cosmetic Ingredient Review (CIR) has not yet published a specific review for Nonapeptide-1 or Nonapeptide-8.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

NONAPEPTIDE-8, largely studied as Nonapeptide-1, is a valuable peptide for addressing hyperpigmentation and promoting a more even, radiant complexion, with additional benefits for skin elasticity and anti-aging.

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