Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

NONAPEPTIDE-40.

Valuable / SKIN CONDITIONING

NONAPEPTIDE-40, also known as Nonapeptide-1, is a precision-engineered biomimetic peptide composed of nine amino acids. It is highly effective in targeting hyperpigmentation, promoting an even skin tone, and offering multifaceted anti-aging benefits.

Summary

Skin brightening Anti-aging Skin conditioning Smoothing Moisturizing

Science

Mechanism of Action

This peptide functions as a competitive antagonist to alpha-melanocyte-stimulating hormone (α-MSH), binding to the melanocortin-1 receptor (MC1R) on melanocytes. This interaction specifically inhibits the activation of tyrosinase, the rate-limiting enzyme in melanin production, thereby reducing melanin synthesis by approximately 33%. Beyond its potent depigmenting action, NONAPEPTIDE-40 stimulates collagen synthesis, improves skin elasticity, provides anti-inflammatory effects, and enhances hydration by boosting natural moisturizing factors.

Research

Clinical Evidence

High confidence
Effective range 0.5–5%
Optimal

2.5%

Key findings

  1. 01 Clinical tests demonstrated a 6.42% increase in skin lightening (ΔL) and a 5.39% improvement in comprehensive skin performance (ΔE) in participants after 56 days of twice-daily application.
  2. 02 Clinical tests showed significant improvements in both skin lightening (ΔL) and comprehensive skin performance (ΔE) after 56 days of twice-daily application.
  3. 03 Recommended for effective skin lightening, enhancing overall skin radiance, and reducing the visibility of dark spots.
  4. 04 Typically recommended for optimal stability and efficacy in improving the appearance of skin tone and reducing the visibility of age spots and dark areas.

Transparency

Dusting Analysis

Not commonly dusted

No data suggests common dusting concerns for this ingredient, which is typically incorporated into formulations in solution form.

The Formula

Formulation

Solubility
Water
Optimal pH 3.5 – 7
0 7 14

Stability

NONAPEPTIDE-40 generally exhibits good stability within various cosmetic bases. To maintain its efficacy, extreme pH conditions and temperatures above 40°C should be avoided. Comprehensive stability testing is recommended during formulation, and long-term storage often requires refrigeration.

Conflicts

  • Formaldehyde-releasing preservatives

Safety

Safety Profile

CIR Status
Unknown
Max tested
2%
Sensitization risk Low

NONAPEPTIDE-40 is generally considered safe for topical use, presenting a low risk of irritation or adverse reactions. Clinical studies indicate it is well-tolerated across most skin types, including sensitive skin. Patch testing is recommended prior to widespread use, particularly for individuals with known sensitivities. The maximum existing dosage for leave-on products in the China Inventory (2021 version) is 2.0%.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

NONAPEPTIDE-40 is a valuable ingredient for precision skincare, effectively addressing hyperpigmentation and signs of aging with excellent skin compatibility and a favorable safety profile.

Related

Similar Ingredients

Finding similar ingredients…