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NONAPEPTIDE-30.

Valuable / SKIN CONDITIONING

NONAPEPTIDE-30, also known as Nonapeptide-1, is a precision-engineered synthetic biomimetic peptide. It is primarily recognized for its ability to target and reduce various forms of hyperpigmentation, promoting a brighter and more even skin tone. Additionally, this versatile ingredient supports skin rejuvenation by reportedly enhancing collagen synthesis, thereby contributing to anti-aging benefits.

Summary

Skin brightening Anti-aging Skin conditioning Moisturizing Smoothing

Science

Mechanism of Action

This peptide acts as a competitive antagonist to alpha-melanocyte-stimulating hormone (α-MSH). By binding to the melanocortin-1 receptor (MC1R) on melanocytes, NONAPEPTIDE-30 effectively blocks the activation signal that triggers melanin synthesis. This mechanism reduces the activity of tyrosinase, the key enzyme involved in pigment production, leading to a decrease in hyperpigmentation. Furthermore, it is understood to promote collagen synthesis, which helps improve skin elasticity and diminish the appearance of fine lines and wrinkles.

Research

Clinical Evidence

High confidence
Effective range 0.5–3%
Optimal

N/A

Key findings

  1. 01 A concentration as low as 0.01% (referring to the active peptide within a 1% or 5% solution) demonstrated significant skin lightening, with a 6.42% increase in skin lightness (ΔL) and a 5.39% increase in comprehensive skin performance (ΔE) after 56 days of use.
  2. 02 Clinical studies have confirmed its effectiveness in visibly lightening sunspots and various hyperpigmentation, with users experiencing enhanced skin tone within 28 days of consistent application.
  3. 03 At a 1% concentration (as a 2500ppm liquid raw material), this peptide stimulated blood circulation by 7.0%, reduced under-eye bags by 16.9%, increased skin luminosity by 3.5%, and decreased wrinkle depth by 15.4% over 7 to 28 days in trials involving 41 women. Recommended usage concentration for skin tone evening and dark spot targeting is 0.5%-3%.

Transparency

Dusting Analysis

Not commonly dusted

Insufficient data available to assess dusting practices for this ingredient.

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 7
0 7 14

Stability

NONAPEPTIDE-30 demonstrates generally good stability in various cosmetic bases. To ensure optimal efficacy and prevent degradation, extreme pH conditions should be avoided. The ideal pH range for formulation is between 5.0 and 7.0, although a broader weakly acidic range of 4.0-7.0 is also suitable for compatibility with other lightening actives. For best results, it is recommended to add the ingredient below 45°C during the final processing stage.

Synergies

  • Antioxidants
  • Vitamins
  • Hydrators

Conflicts

  • Formaldehyde-releasing preservatives

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
2%
Sensitization risk Low

NONAPEPTIDE-30 is considered safe for topical use in cosmetic formulations, exhibiting a low risk of irritation or adverse reactions. Clinical studies indicate it is well-tolerated by most skin types, including sensitive skin. The maximum existing dosage for leave-on products in China (2021 version) is 2.0%. There is no explicit Cosmetic Ingredient Review (CIR) safety assessment for this ingredient in the provided research data. Note: The clinical and safety data presented in this profile refers to 'Nonapeptide-1'; this profile assumes 'NONAPEPTIDE-30' refers to this ingredient.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

NONAPEPTIDE-30 is a valuable peptide for precision skincare, effectively addressing hyperpigmentation and uneven skin tone while simultaneously providing significant anti-aging benefits to enhance overall skin luminosity and texture.

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