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Moumoujus

NONAPEPTIDE-3.

Valuable CAS - / SKIN CONDITIONING

Myristoyl Nonapeptide-3, frequently referred to as Nonapeptide-3, is a sophisticated synthetic lipo-peptide designed to biomimic the extensive actions of retinoic acid. It significantly rejuvenates skin by accelerating cell turnover, stimulating critical collagen production, and enhancing the skin's natural hydration mechanisms. This ingredient also targets hyperpigmentation and calms inflammation for a more even and resilient complexion.

Summary

Anti-aging Cell-communicating Collagen boosting Skin resurfacing Hydrating Brightening Anti-inflammatory Skin barrier support

Science

Mechanism of Action

This biomimetic lipo-peptide operates by mirroring the cellular signaling pathways of retinoic acid. It actively increases dermal cell proliferation and regeneration, leading to enhanced cell turnover. Nonapeptide-3 promotes Type I collagen synthesis by activating fibroblasts and simultaneously inhibits the transcription and translation of the collagen-degrading enzyme Matrix Metalloproteinase-1 (MMP-1). Furthermore, it boosts hyaluronic acid production, which fortifies the skin barrier and significantly improves moisture retention. Its efficacy extends to skin tone correction through the inhibition of melanin production, melanin gene expression, and tyrosinase activity. The peptide also possesses anti-inflammatory properties, reducing pro-inflammatory cytokine production to calm and soothe the skin.

Research

Clinical Evidence

Medium confidence
Effective range 5–10%
Optimal

N/A

Key findings

  1. 01 An ex-vivo study (Symrise) showed that 5% Nonapeptide-3 increased epidermal cellular layers in human skin explants, demonstrating an effect comparable to 0.1% retinoic acid.
  2. 02 In another manufacturer's ex-vivo study (Symrise), 10% Nonapeptide-3 induced a significant 43% increase in Type I collagen in human skin explants, matching the impact observed with 0.1% retinoic acid.

Transparency

Dusting Analysis

Not commonly dusted

With reported effective concentrations ranging from 5% to 10% in ex-vivo studies, Nonapeptide-3 is typically incorporated at levels where it exerts significant biological activity, rather than as a token ingredient.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Specific optimal pH ranges for the stability of Myristoyl Nonapeptide-3 in cosmetic formulations are not readily available in the provided research data. Peptide stability can often vary across different pH environments.

Safety

Safety Profile

CIR Status
Not reviewed
Pregnancy
Caution
Sensitization risk Low

Myristoyl Nonapeptide-3 is generally considered safe for topical use in cosmetic products, with a low risk of skin and eye irritation and reported absence of heavy metals. While adverse reactions are uncommon, patch testing is always advised. Data regarding its safety during pregnancy and breastfeeding is currently insufficient; therefore, consultation with a healthcare professional is recommended for these individuals.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Nonapeptide-3 is a valuable biomimetic peptide offering comprehensive skin benefits, including anti-aging, brightening, and hydration, with a low irritation risk and broad skin type compatibility.

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