Science
Mechanism of Action
This peptide, analogous to Nonapeptide-1, acts as a specific antagonist to alpha-Melanocyte-Stimulating Hormone (α-MSH). By competing for binding on the MC1-R receptor in melanocytes, it effectively blocks tyrosinase activation, thereby inhibiting melanin synthesis and reducing hyper-pigmentation. Furthermore, it supports the synthesis of collagen, which contributes to enhanced skin elasticity and a reduction in the appearance of fine lines.
Research
Clinical Evidence
Medium confidence0.1%
Key findings
- 01 Studies on Nonapeptide-1 indicate that concentrations between 0.0001% and 0.1% are effective for inhibiting melanin synthesis and promoting skin lightening through daily use.
- 02 At a concentration of 100 micromolar in animal models, Nonapeptide-1 was observed to inhibit tyrosinase activity by 25-35% and reduce melanin content in melanocytes by 27-43%.
- 03 Additional research on a different nonapeptide (PWH) demonstrated significant photoprotective effects against UV-induced skin aging in mice models, promoting Type 1 collagen production and blocking the mTOR pathway.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
For optimal stability, store in a cool, dry environment, shielded from light. A temperature range of 2-8°C is typical for storage, with -20°C advised for extended preservation.
Safety
Safety Profile
A specific CIR safety assessment for NONAPEPTIDE-27 AMIDE or Nonapeptide-1 is not available. However, broader reviews of 'Amino Acid Alkyl Amides' and 'Alkoxylated Fatty Amides' suggest safety when formulated to be non-irritating. Notably, Nonapeptide-1 has been observed to present no obvious risks regarding cancer, developmental and reproductive toxicity, or allergies and immunotoxicity, indicating a potentially favorable safety profile for this class of ingredients.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Nonapeptide-27 Amide, drawing from extensive research on Nonapeptide-1, is a valuable peptide for its dual action in precisely inhibiting melanin synthesis for brighter skin and promoting collagen for enhanced anti-aging benefits across all skin types.
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