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Moumoujus

NONAPEPTIDE-17.

Valuable / SKIN CONDITIONING

NONAPEPTIDE-17 is a precision biomimetic peptide engineered to effectively target hyperpigmentation and promote a visibly uniform skin tone. It further offers adjunctive benefits by enhancing skin elasticity and contributing to comprehensive skin rejuvenation.

Summary

Skin Lightening Hyperpigmentation Reduction Even Skin Tone Promotion Anti-aging Skin Conditioning Smoothing Moisturising

Science

Mechanism of Action

NONAPEPTIDE-17 functions by specifically targeting the melanocortin-1 receptor (MC1R) on melanocytes, acting as a competitive inhibitor to alpha-melanocyte-stimulating hormone (α-MSH). This interference disrupts the critical signaling cascade that normally activates tyrosinase, the primary enzyme in melanin synthesis. By reducing melanin production and deposition, the peptide leads to measurable skin brightening and a reduction in hyperpigmentation. Additionally, NONAPEPTIDE-17 is understood to support collagen synthesis, which contributes to improved skin elasticity, a reduction in the appearance of fine lines, and potentially enhanced cellular turnover.

Research

Clinical Evidence

High confidence
Effective range 0.0001–0.0005%
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 7
0 7 14

Stability

Optimal stability and efficacy for NONAPEPTIDE-17 are observed within a pH range of 4.0 to 7.0, with some manufacturers specifically recommending 5.0 to 7.0. For optimal preservation of integrity, the ingredient should be incorporated into formulations at temperatures below 45°C, and the final product should avoid sustained exposure to temperatures exceeding 40°C.

Conflicts

  • Formaldehyde-releasing preservatives
  • Paraben
  • Benzotriazolyl Dodecyl P-Cresol

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

NONAPEPTIDE-17 is generally regarded as safe for topical application in cosmetic formulations, demonstrating a low propensity for irritation or adverse reactions. Clinical studies indicate it is well-tolerated across diverse skin types, including sensitive skin. No discernible risks have been identified concerning carcinogenicity, developmental/reproductive toxicity, or immunotoxicity. While approved for use in China and not listed as restricted in EU Annex II or III, patch testing is recommended, particularly for individuals with pre-existing sensitivities.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

NONAPEPTIDE-17 is a valuable biomimetic peptide demonstrating significant clinical efficacy in reducing hyperpigmentation and promoting an even, brighter skin tone, with complementary benefits for skin elasticity and overall rejuvenation.

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