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Moumoujus

NICOTINOYL TRIPEPTIDE-1.

Valuable CAS - / ANTIOXIDANT, CHELATING, SKIN PROTECTING

Nicotinoyl Tripeptide-1 is a sophisticated peptide, combining amino acid sequences with niacin to deliver multifaceted skin benefits. It functions as a robust antioxidant and chelating agent, protecting skin from environmental aggressors, while actively signaling for cellular regeneration to enhance firmness and diminish visible signs of aging.

Summary

Antioxidant Skin Protecting Chelating Moisturizing Anti-aging Evens skin tone Barrier repair & moisturization Collagen stimulation Skin regeneration Firming

Science

Mechanism of Action

This ingredient operates on multiple fronts. As a peptide, it signals the skin's intrinsic repair mechanisms, prompting cellular regeneration and reinforcing the skin's structural integrity. This stimulation is believed to boost the production of vital skin proteins such as collagen, fibronectin, elastin, and laminin, which collectively lead to improved skin firmness and a reduction in fine lines and wrinkles. Furthermore, its niacin component contributes antioxidant properties, neutralizing oxygen-promoted reactions that can degrade skin and product stability. It also acts as a chelating agent, binding metal ions that could otherwise destabilize cosmetic formulations or negatively impact skin appearance.

Research

Clinical Evidence

Medium confidence
Effective range 1–30%
Optimal

0.0003%

Key findings

  1. 01 Peptide ingredients are customarily used at concentrations between 1 ppm and 30 ppm, with less than 10 ppm being typical in cosmetic products. While specific efficacy studies for Nicotinoyl Tripeptide-1 at defined concentrations are limited, a relevant clinical study on Palmitoyl Tripeptide-1 (a related peptide) demonstrated a statistically significant anti-wrinkle effect. This study, involving twice-daily application of a 3 ppm cream for 4 weeks, resulted in decreased wrinkle length and depth. Nicotinoyl Tripeptide-1 is expected to deliver similar improvements in skin tone, reduction of fine lines, and support for collagen synthesis, based on its structure and supplier information.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 4.5 – 6.5
0 7 14

Stability

This ingredient maintains stability for 24 months from manufacture when stored at -20ºC to -15ºC in a freezer, protected from light, and kept airproofed. Its optimal pH range of 4.5 to 6.5, observed with related peptides, suggests best stability in mildly acidic to neutral formulations.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
0.001%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that Tripeptide-1 and its related fatty acyl derivatives, including Nicotinoyl Tripeptide-1, are safe for use in cosmetics at current concentrations and practices. SkinSAFE further categorizes it as free from common irritants such as fragrances, parabens, gluten, and dyes, indicating broad compatibility and a low risk profile for sensitive skin.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Nicotinoyl Tripeptide-1 is a valuable, well-tolerated ingredient that provides comprehensive anti-aging and skin protective benefits by stimulating intrinsic skin repair mechanisms and offering antioxidant defense.

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